Derijcke A, Eerens A, Carels C
Department of Orthodontics, University of Leuven School of Dentistry, Belgium.
Br J Oral Maxillofac Surg. 1996 Dec;34(6):488-94. doi: 10.1016/s0266-4356(96)90242-9.
We have reviewed epidemiological studies on the incidence of oral clefts in several regions of the world, but mainly in Europe. The incidence ranges from 1.0/1000 to 2.21/1000. The highest incidence was in Czechoslovakia (1.81/1000), followed by France (1.75/1000), Finland (1.74/1000), Denmark (1.69/1000), Belgium and the Netherlands (1.47/1000), Italy (1.33/1000), California (1.12/1000) and South America (1.0/1000). The data from Denmark and Finland appeared to be the most reliable. All studies showed a higher incidence of cleft lip and/or palate (CL(P)) compared with cleft palate (CP). There was a predominance of girls in the CP group, while the CL(P) group comprised mainly boys. The left side was affected twice as often as the right side. Black children had a lower incidence than white children. An attempt was made in several reports to clarify the cause of oral clefts, but opinions are contradictory.
我们回顾了世界上几个地区，主要是欧洲地区关于口腔裂隙发病率的流行病学研究。发病率范围为1.0/1000至2.21/1000。发病率最高的是捷克斯洛伐克（1.81/1000），其次是法国（1.75/1000）、芬兰（1.74/1000）、丹麦（1.69/1000）、比利时和荷兰（1.47/1000）、意大利（1.33/1000）、加利福尼亚（1.12/1000）和南美洲（1.0/1000）。来自丹麦和芬兰的数据似乎最可靠。所有研究表明，唇裂和/或腭裂（CL(P)）的发病率高于腭裂（CP）。CP组中女孩占多数，而CL(P)组主要由男孩组成。左侧受累的频率是右侧的两倍。黑人儿童的发病率低于白人儿童。几份报告试图阐明口腔裂隙的原因，但观点相互矛盾。
