Michal M, Zámecník M, Gogora M, Mukensnabl P, Neubauer L
Sikls Department of Pathological Anatomy, Charles University, Pilsen, Czech Republic.
Histopathology. 1996 Dec;29(6):549-55. doi: 10.1046/j.1365-2559.1996.d01-533.x.
We describe four cases of ectopic hamartomatous thymoma with unusual morphological features. In cases 1 and 2 we found a dysplastic glandular component which was often arranged in a cribriform pattern bridging several glandular spaces. In case 2 we found solid adenocarcinomatous areas with infiltrative edges. Case 3 showed widespread smooth muscle differentiation within the spindle epithelial cell component, the presence of multiple clear cell glands which contained a distinct myoepithelial layer and an overall picture which vaguely resembled a sclerosing adenosis of the breast. Case 4 contained frequent foci of multinucleated giant epithelial cells within the markedly cellular spindle cell component: it also showed multiple, hypocellular, myxoid areas containing eosinophilic cords and pearls of squamous cells, and resembled squamous cell carcinoma with a sarcomatoid spindle cell component. We could not find any evidence of a thymic origin or of thymic differentiation in our four cases or in any other reported cases of ectopic hamartomatous thymoma. We believe that ectopic hamartomatous thymomas manifest salivary gland differentiation.
我们描述了4例具有不寻常形态特征的异位错构瘤性胸腺瘤。在病例1和病例2中，我们发现了发育异常的腺性成分，其常呈筛状排列，横跨多个腺腔。在病例2中，我们发现了具有浸润边缘的实性腺癌区域。病例3在梭形上皮细胞成分内显示广泛的平滑肌分化，存在多个透明细胞腺，其中含有明显的肌上皮层，整体表现与乳腺硬化性腺病有一定相似。病例4在细胞丰富的梭形细胞成分内有频繁的多核巨上皮细胞灶；它还显示多个细胞稀少的黏液样区域，含有嗜酸性条索和鳞状细胞珠，类似具有肉瘤样梭形细胞成分的鳞状细胞癌。在我们的4例病例以及其他任何已报道的异位错构瘤性胸腺瘤病例中，我们均未发现胸腺起源或胸腺分化的任何证据。我们认为异位错构瘤性胸腺瘤表现出唾液腺分化。
