Rosai J, Limas C, Husband E M
Am J Surg Pathol. 1984 Jul;8(7):501-13.
Five cases of a distinctive tumor located in the soft tissues of the lower neck in adults are described. The lesion is characterized microscopically by the presence of four components: cellular areas made up of spindle elements; epithelial islands composed of solid nests, trabeculae and cysts; mature adipose tissue; and lymphocytes, sometimes arranged in a Hassall's corpuscle-like fashion. Electron microscopy and immunostaining for keratin showed that the spindle cell component was of epithelial nature. These tumors were supraclavicular or suprasternal in location, and no local recurrence has developed in any case following local resection. We interpret these lesions as benign tumors arising on the basis of a developmental defect. We think that they are derived from the third branchial arch and that they are composed of abnormal thymic tissue.
本文描述了5例发生于成人下颈部软组织的独特肿瘤。该病变在显微镜下的特征为存在四种成分：由梭形细胞构成的细胞区域；由实性巢、小梁和囊肿组成的上皮岛；成熟脂肪组织；以及淋巴细胞，有时呈哈氏小体样排列。电镜检查及角蛋白免疫染色显示梭形细胞成分具有上皮性质。这些肿瘤位于锁骨上或胸骨上，局部切除后均未出现局部复发。我们将这些病变解释为基于发育缺陷产生的良性肿瘤。我们认为它们起源于第三鳃弓，由异常胸腺组织构成。
