情感障碍患者血小板中对血清素的钙反应增强。
Enhanced calcium response to serotonin in platelets from patients with affective disorders.
作者信息
Yamawaki S, Kagaya A, Okamoto Y, Shimizu M, Nishida A, Uchitomi Y
机构信息
Department of Psychiatry and Neurosciences, Hiroshima University, School of Medicine, Japan.
出版信息
J Psychiatry Neurosci. 1996 Nov;21(5):321-4.
Abstract
In this report we have investigated the intracellular calcium (Ca2+) mobilization mediated by serotonin 5-HT2A receptors in the platelets of 13 patients with bipolar disorder and 12 patients with major depression in comparison with 15 healthy control subjects. We found an enhanced intracellular Ca2+ rise in response to 5-HT in platelets from both bipolar patients and patients with major depression. The 5-HT2A receptor-mediated intracellular Ca2+ signaling mechanism may have an important role in the pathophysiology of affective disorders.
摘要
在本报告中，我们研究了13例双相情感障碍患者和12例重度抑郁症患者血小板中5-羟色胺（5-HT）2A受体介导的细胞内钙（Ca2+）动员情况，并与15名健康对照者进行了比较。我们发现，双相情感障碍患者和重度抑郁症患者的血小板对5-HT的反应均有细胞内Ca2+升高增强的情况。5-HT2A受体介导的细胞内Ca2+信号传导机制可能在情感障碍的病理生理学中起重要作用。
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