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J Psychiatry Neurosci. 1996 Nov;21(5):321-4.
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Homologous desensitization of serotonin 5-HT2 receptor-stimulated intracellular calcium mobilization in C6BU-1 glioma cells via a mechanism involving a calmodulin pathway.
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Elevated intracellular calcium levels after 5-HT2 receptor stimulation in platelets of depressed patients.抑郁症患者血小板中5-羟色胺2型受体受刺激后细胞内钙水平升高。
Biol Psychiatry. 1993 Oct 15;34(8):565-8. doi: 10.1016/0006-3223(93)90201-n.
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Serotonergic markers in platelets of patients with major depression: upregulation of 5-HT2 receptors.重度抑郁症患者血小板中的血清素能标志物：5-HT2受体上调。
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Serotonin-induced platelet calcium mobilization is enhanced in mania.血清素诱导的血小板钙动员在躁狂症中增强。
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Inositol trisphosphate and diacylglycerol as second messengers.肌醇三磷酸和二酰甘油作为第二信使。
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Serotonin 5-HT2 receptor binding on blood platelets--a peripheral marker for depression?
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Increased serotonin2 and beta-adrenergic receptor binding in the frontal cortices of suicide victims.
Arch Gen Psychiatry. 1986 Oct;43(10):954-9. doi: 10.1001/archpsyc.1986.01800100048007.
8
Increased serotonin2 (5-HT2) receptor binding as measured by 3H-lysergic acid diethylamide (3H-LSD) in the blood platelets of depressed patients.通过3H-麦角酸二乙酰胺（3H-LSD）测定，抑郁症患者血小板中5-羟色胺2（5-HT2）受体结合增加。
Life Sci. 1989;44(11):725-34. doi: 10.1016/0024-3205(89)90384-6.
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Increased platelet intracellular calcium concentration in patients with bipolar affective disorders.双相情感障碍患者血小板细胞内钙浓度升高。
Arch Gen Psychiatry. 1989 Jul;46(7):632-8. doi: 10.1001/archpsyc.1989.01810070058010.
10
Serotonergic measures in the brains of suicide victims: 5-HT2 binding sites in the frontal cortex of suicide victims and control subjects.自杀受害者大脑中的血清素能指标：自杀受害者及对照对象额叶皮质中的5-羟色胺2型（5-HT2）结合位点。
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情感障碍患者血小板中对血清素的钙反应增强。

Enhanced calcium response to serotonin in platelets from patients with affective disorders.

作者信息

Yamawaki S, Kagaya A, Okamoto Y, Shimizu M, Nishida A, Uchitomi Y

机构信息

Department of Psychiatry and Neurosciences, Hiroshima University, School of Medicine, Japan.

出版信息

J Psychiatry Neurosci. 1996 Nov;21(5):321-4.

PMID:8973051
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1188796/
Abstract

In this report we have investigated the intracellular calcium (Ca2+) mobilization mediated by serotonin 5-HT2A receptors in the platelets of 13 patients with bipolar disorder and 12 patients with major depression in comparison with 15 healthy control subjects. We found an enhanced intracellular Ca2+ rise in response to 5-HT in platelets from both bipolar patients and patients with major depression. The 5-HT2A receptor-mediated intracellular Ca2+ signaling mechanism may have an important role in the pathophysiology of affective disorders.

摘要

在本报告中，我们研究了13例双相情感障碍患者和12例重度抑郁症患者血小板中5-羟色胺（5-HT）2A受体介导的细胞内钙（Ca2+）动员情况，并与15名健康对照者进行了比较。我们发现，双相情感障碍患者和重度抑郁症患者的血小板对5-HT的反应均有细胞内Ca2+升高增强的情况。5-HT2A受体介导的细胞内Ca2+信号传导机制可能在情感障碍的病理生理学中起重要作用。