Tanigawa N, Amaya H, Matsumura M, Katoh Y, Kitaoka A, Aotake T, Shimomatsuya T, Rosenwasser O A, Iki M
Second Department of Surgery, Fukui Medical School, Japan.
Cancer Lett. 1996 Nov 29;108(2):281-90. doi: 10.1016/s0304-3835(96)04482-5.
To investigate the relationship between tumor angiogenesis and the expression of platelet-derived endothelial cell growth factor/thymidine phosphorylase (PD-ECGF/dThdPase) and between patients' survival and the expression of PD-ECGF/ dThdPase in human gastric carcinoma tissues, we performed immunohistochemical studies with anti-PD-ECGF/dThdPase and anti-CD34 monoclonal antibodies. Out of 154 gastric carcinoma tissue samples, 61 (40%) were evaluated as PD-ECGF/ dThdPase-positive. The expression of PD-ECGF/dThdPase was significantly associated with the intratumoral microvessel counts (P < 0.0001) and the incidence of hematogenous metastasis (P < 0.05). Intratumoral vessel counts were significantly correlated with overall survival of 154 patients (P < 0.000001). Cox proportional hazards model showed that tumor vasculature was an independent and strong prognostic variable. However, the prevalence of the expression of PD-ECGF did not associate the overall survival. We suggest that expression of PD-ECGF/dThdPase plays a role in the promotion of angiogenesis in human gastric carcinomas, without any definite influence on patient's survival.
为了研究肿瘤血管生成与血小板衍生内皮细胞生长因子/胸苷磷酸化酶（PD - ECGF/dThdPase）表达之间的关系，以及人类胃癌组织中患者生存率与PD - ECGF/dThdPase表达之间的关系，我们使用抗PD - ECGF/dThdPase和抗CD34单克隆抗体进行了免疫组织化学研究。在154份胃癌组织样本中，61份（40%）被评估为PD - ECGF/dThdPase阳性。PD - ECGF/dThdPase的表达与瘤内微血管计数显著相关（P < 0.0001），与血行转移发生率显著相关（P < 0.05）。瘤内血管计数与154例患者的总生存率显著相关（P < 0.000001）。Cox比例风险模型显示肿瘤血管系统是一个独立且强大的预后变量。然而，PD - ECGF表达的发生率与总生存率无关。我们认为PD - ECGF/dThdPase的表达在人类胃癌血管生成促进中起作用，对患者生存率没有任何明确影响。
