骨密度、质量和结构的无创评估进展

Advances in the noninvasive assessment of bone density, quality, and structure.

作者信息

Genant H K, Lang T F, Engelke K, Fuerst T, Glüer C, Majumdar S, Jergas M

机构信息

Skeletal Section, Radiology Department, University of California, San Francisco, 505 Parnassus, M392, San Francisco, CA 94143-0628, USA.

出版信息

Calcif Tissue Int. 1996;59 Suppl 1:S10-5. doi: 10.1007/s002239900169.

DOI:10.1007/s002239900169

PMID:8974723

Abstract

Recent advances in the development of methods to assess the skeleton noninvasively have contributed to screening for risk of osteoporosis, early detection of the disease, and effective monitoring of its progression and response to therapy. The capability now exists to evaluate the peripheral, central, or entire skeleton as well as the trabecular bone or cortical bone envelopes accurately and precisely, with the capacity to determine bone strength and predict fracture risk. In this article we examine the current and future capabilities of quantitative computed tomography (QCT), quantitative ultrasound (QUS), and magnetic resonance microscopy (muMR) to assess architectural and densitometric properties of the skeleton to enhance the prediction of fracture risk.

摘要

近年来，无创评估骨骼方法的发展取得了显著进展，这有助于骨质疏松症风险筛查、疾病的早期检测以及对其进展和治疗反应的有效监测。目前已具备准确、精确地评估外周、中央或整个骨骼以及小梁骨或皮质骨包膜的能力，能够确定骨强度并预测骨折风险。在本文中，我们探讨了定量计算机断层扫描（QCT）、定量超声（QUS）和磁共振显微镜（μMR）评估骨骼结构和密度特性以增强骨折风险预测的当前及未来能力。