乳酸杆菌对阴道加德纳菌甲硝唑敏感株和耐药株的体外生长抑制作用
Growth inhibition of metronidazole-susceptible and metronidazole-resistant strains of Gardnerella vaginalis by Lactobacilli in vitro.
作者信息
McLean N W, McGroarty J A
机构信息
Department of Biological Sciences, Glasgow Caledonian University, United Kingdom.
出版信息
Appl Environ Microbiol. 1996 Mar;62(3):1089-92. doi: 10.1128/aem.62.3.1089-1092.1996.
Abstract
Metronidazole resistance was produced in susceptible Gardnerella vaginalis after subculture in the presence of metronidazole. Metronidazole-resistant gardnerellae were less susceptible to growth inhibition by Lactobacillus culture filtrates. A low pH (+/- 4) and lactic acid accounted for 60 to 95% of inhibitory activity, and H2O2 accounted for only 0 to 30%. However, in the presence of myeloperoxidase, H2O2-producing lactobacilli decreased the viability of metronidazole-susceptible gardnerellae 2,000-fold.
摘要
在甲硝唑存在的情况下传代培养后，敏感的阴道加德纳菌产生了甲硝唑耐药性。耐甲硝唑的加德纳菌对乳酸杆菌培养滤液的生长抑制作用较不敏感。低pH值（±4）和乳酸占抑制活性的60%至95%，而过氧化氢仅占0%至30%。然而，在髓过氧化物酶存在的情况下，产生过氧化氢的乳酸杆菌可使敏感的甲硝唑加德纳菌的活力降低2000倍。
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