Burnett A L
Department of Urology, James Buchanan Brady Urological Institute, Johns Hopkins Hospital, Baltimore, Maryland, USA.
J Urol. 1997 Jan;157(1):320-4.
The significance of nitric oxide in the physiology of the penis was evaluated, including its role in pathophysiological mechanisms and pathological consequences involving this organ.
Animal and human studies pertaining to nitric oxide in the penis were reviewed and analyzed in the context of current descriptions of the molecular biology and physiological effects of this chemical.
Potential sources of nitric oxide in the penis include neurons, sinusoidal endothelium and corporeal smooth muscle cells. Nitric oxide is perceived to exert a host of functional roles by binding with specific molecular targets. Its synthesis and action in the penis are influenced by many different regulatory factors.
Nitric oxide exerts a significant role in the physiology of the penis, operating chiefly as the principal mediator of erectile function. Alterations in the biology of nitric oxide likely account for various forms of erectile dysfunction. The diverse physiological roles of nitric oxide suggest that it may also directly contribute to or cause pathological consequences involving the penis.
评估一氧化氮在阴茎生理学中的意义，包括其在涉及该器官的病理生理机制和病理后果中的作用。
在当前对这种化学物质的分子生物学和生理效应描述的背景下，对与阴茎中一氧化氮相关的动物和人体研究进行了综述和分析。
阴茎中一氧化氮的潜在来源包括神经元、窦状内皮细胞和海绵体平滑肌细胞。一氧化氮被认为通过与特定分子靶点结合发挥多种功能作用。其在阴茎中的合成和作用受许多不同调节因子的影响。
一氧化氮在阴茎生理学中发挥重要作用，主要作为勃起功能的主要介质。一氧化氮生物学的改变可能是各种形式勃起功能障碍的原因。一氧化氮的多种生理作用表明它也可能直接导致或引发涉及阴茎的病理后果。
