Duch-Samper A M, Menezo J L, Hurtado-Sarrió M, Maldonado M J, Checa-Flores S, Diaz-Llopis M
Ophthalmology Department, La Fe Hospital, Valencia, Spain.
Ophthalmic Surg Lasers. 1996 Dec;27(12):1005-11.
An attempt was made to establish the effect of an intravenous antibiotic on anterior chamber (AC) fluid contamination when administered before surgery.
A prospective study of AC contamination was conducted in 60 patients undergoing extracapsular cataract extraction (ECCE)/intraocular lens (IOL) implantation. The final 20 patients received 1 g of intravenous imipenem 1 hour before surgery.
There were 4 positive AC cultures from the 20 patients in the imipenem group, and 13 positive AC cultures from the 40 control patients (P = .4, chi-square test). Of the 60 eyes, 17 had positive AC aspirate cultures and 23 had positive conjunctival smears. Only in one instance was the microorganism isolated from each case the same (1.7%).
An insignificant decrease in AC contamination was observed when intravenous imipenem was used before surgery. The results also suggest that conjunctiva might not be the main source of contamination during surgery.
旨在探讨术前静脉注射抗生素对前房（AC）液污染的影响。
对60例行白内障囊外摘除术（ECCE）/人工晶状体（IOL）植入术的患者进行AC污染的前瞻性研究。最后20例患者在手术前1小时静脉注射1克亚胺培南。
亚胺培南组20例患者中有4例AC培养阳性，40例对照患者中有13例AC培养阳性（P = 0.4，卡方检验）。60只眼中，17只AC抽吸培养阳性，23只结膜涂片阳性。仅在1例中，从每个病例分离出的微生物相同（1.7%）。
术前使用静脉亚胺培南时，AC污染的减少不显著。结果还表明，结膜可能不是手术期间污染的主要来源。
