Booji A, Biewenga-Booji C M, Huber-Bruning O, Cornelis C, Jacobs J W, Bijlsma J W
Department of Rheumatology and Clinical Immunology, University Hospital Utrecht, The Netherlands.
Ann Rheum Dis. 1996 Nov;55(11):811-5. doi: 10.1136/ard.55.11.811.
To examine the possible beneficial effect of androgens in postmenopausal women with active rheumatoid arthritis.
107 women participated in a double blind placebo controlled trial to evaluate the effect of 50 mg testosterone propionate intramuscularly every two weeks for one year.
An improvement in ESR, Dutch health assessment questionnaire, and pain was noted. In addition, 21% of patients treated with testosterone fulfilled the ACR improvement criteria after one year, versus only 4% of the placebo group. The treatment was well tolerated.
Testosterone may improve the general wellbeing of postmenopausal women with active rheumatoid arthritis.
研究雄激素对患有活动性类风湿关节炎的绝经后女性可能产生的有益作用。
107名女性参与了一项双盲安慰剂对照试验,以评估每两周肌肉注射50毫克丙酸睾酮,持续一年的效果。
观察到红细胞沉降率、荷兰健康评估问卷及疼痛情况有所改善。此外,接受睾酮治疗的患者中有21%在一年后达到了美国风湿病学会(ACR)改善标准,而安慰剂组只有4%。该治疗耐受性良好。
睾酮可能改善患有活动性类风湿关节炎的绝经后女性的总体健康状况。