辅助雌激素治疗可提高绝经后类风湿关节炎女性的骨密度。
Adjuvant oestrogen treatment increases bone mineral density in postmenopausal women with rheumatoid arthritis.
作者信息
van den Brink H R, Lems W F, van Everdingen A A, Bijlsma J W
机构信息
Department of Rheumatology, University Hospital Utrecht, The Netherlands.
出版信息
Ann Rheum Dis. 1993 Apr;52(4):302-5. doi: 10.1136/ard.52.4.302.
OBJECTIVES
The beneficial effect of oestrogens on bone mineral density in women with osteoporosis is well known. Patients with rheumatoid arthritis (RA) are at risk for osteoporosis. A study was therefore set up to investigate the effects of adjuvant oestrogen treatment on bone metabolism and bone mineral density in postmenopausal women with RA.
METHODS
Forty postmenopausal women with active RA were admitted to a placebo controlled, double blind study investigating the beneficial effect of adjuvant oestradiols or placebo on bone metabolism and bone mineral density. Thirty three patients completed 52 weeks of treatment.
RESULTS
At the start both treatment groups were comparable for all parameters. In the oestrogen group serum concentrations of osteocalcin decreased and concentrations of sex hormone binding globulin increased during the study. Bone mineral density measured by dual energy x ray absorptiometry increased significantly in the lumbar vertebral spine and femoral neck in the oestrogen group compared with the placebo group.
CONCLUSIONS
This study shows that the use of adjuvant oestrogens in post-menopausal women with active RA increases bone mineral density.
目的
雌激素对骨质疏松女性骨矿物质密度的有益作用已广为人知。类风湿关节炎（RA）患者存在骨质疏松风险。因此开展了一项研究，以调查辅助雌激素治疗对绝经后RA女性骨代谢和骨矿物质密度的影响。
方法
40名患有活动性RA的绝经后女性被纳入一项安慰剂对照、双盲研究，该研究调查辅助雌二醇或安慰剂对骨代谢和骨矿物质密度的有益作用。33名患者完成了52周的治疗。
结果
在研究开始时，两个治疗组的所有参数都具有可比性。在雌激素组中，骨钙素的血清浓度在研究期间下降，性激素结合球蛋白的浓度上升。与安慰剂组相比，雌激素组通过双能X线吸收法测量的腰椎和股骨颈骨矿物质密度显著增加。
结论
本研究表明，在患有活动性RA的绝经后女性中使用辅助雌激素可增加骨矿物质密度。
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