Erken E, Güneşaçar R, Ozbek S, Konca K
Department of Rheumatology, Faculty of Medicine, Cukurova University, Balcal, Adana, Turkey.
Ann Rheum Dis. 1996 Nov;55(11):852-5. doi: 10.1136/ard.55.11.852.
To investigate serum soluble interleukin-2 receptor (sIL-2R) in familial Mediterranean fever (FMF) and assess its role in acute FMF crisis.
Serum sIL-2R concentrations were measured in patients with FMF during acute crises and during inactive periods of the disease, using an immunoenzymatic assay kit. Twenty four FMF patients during acute crisis (active FMF), 17 patients with inactive FMF, 24 healthy controls, and 20 active patients with rheumatoid arthritis (as a disease control group) were studied.
Serum sIL-2R concentrations were increased during an acute FMF crisis compared with the values in inactive FMF patients and healthy controls (P = 0.0105 and P = 0.0012 respectively), while there was no significant difference between the mean values in active FMF and rheumatoid arthritis patients (P = 0.7325). In 14 of the FMF group whose blood samples were available in both active and inactive phases, sIL-2R concentrations were significantly higher in an acute attack than in an attack-free period (P = 0.027).
An increase in sIL-2R may be a result of hyperreactivity of IL-2R-expressing cells during an acute inflammatory attack of FMF.
研究家族性地中海热（FMF）患者血清可溶性白细胞介素-2受体（sIL-2R）水平，并评估其在FMF急性发作中的作用。
采用免疫酶分析试剂盒，检测FMF患者急性发作期和疾病缓解期的血清sIL-2R浓度。研究对象包括24例FMF急性发作期患者（活动期FMF）、17例FMF缓解期患者、24例健康对照者以及20例类风湿关节炎活动期患者（作为疾病对照组）。
与FMF缓解期患者及健康对照者相比，FMF急性发作期患者血清sIL-2R浓度升高（分别为P = 0.0105和P = 0.0012），而活动期FMF患者与类风湿关节炎患者的血清sIL-2R浓度均值无显著差异（P = 0.7325）。在14例在活动期和缓解期均采集血样的FMF患者中，急性发作期的sIL-2R浓度显著高于无发作期（P = 0.027）。
sIL-2R升高可能是FMF急性炎症发作期间表达IL-2R的细胞反应过度的结果。
