Folgosa E, Osman N B, Gonzalez C, Hägerstrand I, Bergström S, Ljungh A
Department of Microbiology, Faculty of Medicine, Eduardo Mondlane University, Maputo, Mozambique.
Genitourin Med. 1996 Oct;72(5):339-42. doi: 10.1136/sti.72.5.339.
To elucidate the role of current syphilis as a risk factor for foetal death.
Sera were obtained from 57 women with third trimester foetal death (cases) and 58 women with foetus alive (controls) matched for age and parity. All sera reactive in qualitative Rapid Plasma Reagin (RPR) analyses were tested with serial twofold dilutions to determine endpoint flocculation titres and tested with the micro-haemagglutination assay for Treponema pallidum (MHA-TP). Placental biopsies were sectioned and stained by haematoxylin-eosin and Warthin-Starry for light microscopy.
Central Hospital, in Maputo, Mozambique, from January 1990 to June 1991.
The MHA-TP was reactive in 42% of cases and in 12% of controls (OR = 5.3; 95% CI: 1.9-15.4). The RPR card test was reactive at the dilution of 1.32 or greater in 28% of cases and in 7% of controls. All these results were confirmed by MHA-TP (OR = 5.3; 95% CI: 1.5-15.4). In 9/28 (32%) MHA-TP seroreactive women (7 cases and 2 controls) placental morphological changes indicated syphilitic infection.
MHA-TP seroreactivity and high titre RPR were associated with stillbirth. Morphological changes presumptive of syphilis infection were found in 32% placentas histologically studied. Syphilis is a risk factor for foetal death in Maputo, Mozambique.
阐明当前梅毒作为胎儿死亡危险因素的作用。
采集了57例孕晚期胎儿死亡妇女（病例组）和58例年龄及产次匹配的活胎妇女（对照组）的血清。对所有定性快速血浆反应素（RPR）分析呈阳性反应的血清进行系列两倍稀释检测，以确定终点凝集效价，并采用梅毒螺旋体微量血凝试验（MHA-TP）进行检测。胎盘活检组织进行苏木精-伊红染色和Warthin-Starry染色，用于光学显微镜检查。
莫桑比克马普托中心医院，1990年1月至1991年6月。
MHA-TP检测中，病例组42%呈阳性反应，对照组12%呈阳性反应（比值比[OR]=5.3；95%可信区间[CI]：1.9-15.4）。RPR卡片试验中，病例组28%在稀释度为1:32或更高时呈阳性反应，对照组7%呈阳性反应。所有这些结果均得到MHA-TP的证实（OR=5.3；95%CI：1.5-15.4）。在9/28（32%）MHA-TP血清反应阳性的妇女中（7例病例和2例对照），胎盘形态学改变提示梅毒感染。
MHA-TP血清反应性和高滴度RPR与死产相关。在组织学研究的胎盘中，32%发现有疑似梅毒感染的形态学改变。在莫桑比克马普托，梅毒是胎儿死亡的一个危险因素。
