Watts T E, Larsen S A, Brown S T
Bull World Health Organ. 1984;62(5):803-8.
Sera were obtained from 266 mothers of singleton stillborn babies (cases) and 266 mothers of live-born babies (controls), matched for parity, who delivered at the University Teaching Hospital, Lusaka, Zambia, between October 1979 and April 1980. Tests were performed on 262 samples from cases and 261 from controls. The microhaemagglutination assay for Treponema pallidum (MHA-TP) was reactive in 54% of cases and 29% of controls; the rapid plasma reagin (RPR) 18-mm circle card test was reactive at a dilution of 1:16 or greater in 29% of cases and in 3.5% of controls. Both these differences are highly significant.Sera from cases and controls were further examined for evidence of cytomegalovirus, human (alpha) herpesvirus, hepatitis B virus, toxoplasma, and plasmodium infections. The only difference between sera from cases and controls was that cytomegalovirus antibody titres >/= 1:1024 occurred more often among cases. There was no relationship between antibody titre and birth weight.The results of this study emphasize the importance of screening pregnant women for syphilis. Treatment of those found to be infected should help prevent stillbirths due to syphilis.
血清取自1979年10月至1980年4月间在赞比亚卢萨卡大学教学医院分娩的266名单胎死产婴儿的母亲（病例组）和266名活产婴儿的母亲（对照组），两组按产次匹配。对病例组的262份样本和对照组的261份样本进行了检测。梅毒螺旋体微量血凝试验（MHA - TP）在54%的病例组和29%的对照组中呈阳性反应；快速血浆反应素（RPR）18毫米环形卡片试验在1:16或更高稀释度下，29%的病例组呈阳性反应，3.5%的对照组呈阳性反应。这两个差异均具有高度显著性。对病例组和对照组的血清进一步检测巨细胞病毒、人（α）疱疹病毒、乙型肝炎病毒、弓形虫和疟原虫感染的证据。病例组和对照组血清之间的唯一差异是，病例组中巨细胞病毒抗体滴度≥1:1024的情况更为常见。抗体滴度与出生体重之间没有关系。本研究结果强调了对孕妇进行梅毒筛查的重要性。对检测出感染的孕妇进行治疗应有助于预防因梅毒导致的死产。
