黑腹果蝇中具有母性效应表型的合子致死突变。II. 由P因子诱导突变鉴定的第二和第三染色体上的基因座
Zygotic lethal mutations with maternal effect phenotypes in Drosophila melanogaster. II. Loci on the second and third chromosomes identified by P-element-induced mutations.
作者信息
Perrimon N, Lanjuin A, Arnold C, Noll E
机构信息
Department of Genetics, Howard Hughes Medical Institute, Harvard Medical School, Boston, Massachusetts 02115, USA.
出版信息
Genetics. 1996 Dec;144(4):1681-92. doi: 10.1093/genetics/144.4.1681.
Abstract
Screens for zygotic lethal mutations that are associated with specific maternal effect lethal phenotypes have only been conducted for the X chromosome. To identify loci on the autosomes, which represent four-fifths of the Drosophila genome, we have used the autosomal "FLP-DFS" technique to screen a collection of 496 P element-induced mutations established by the Berkeley Drosophila Genome Project. We have identified 64 new loci whose gene products are required for proper egg formation or normal embryonic development.
摘要
仅针对X染色体开展了与特定母体效应致死表型相关的合子致死突变筛选。为了鉴定常染色体上的基因座（常染色体占果蝇基因组的五分之四），我们使用常染色体“FLP-DFS”技术，对由伯克利果蝇基因组计划建立的496个P元件诱导突变的集合进行了筛选。我们鉴定出了64个新的基因座，其基因产物对于正常卵子形成或正常胚胎发育是必需的。
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