Klein M, Aubert V, Weryha G, Leclère J
Clinique médicale et endocrinologique, Hôpitaux de Brabois, Centre hospitalier universitaire de Nancy, Vandoeuvre-lès-Nancy.
Rev Prat. 1996 Dec 1;46(19):2288-95.
Thyroid diseases are the most prevalent endocrine diseases. Faced with a thyroid enlargement or nodule, it is a challenge for the physician to determine with the best sensibility and specificity and the least cost which one are benign tumours and which are malignant neoplasms that need to be removed. The prevalence of solitary nodules is 1 to 5%. Only 2 to 12% of these nodules are cancers. Papillary and follicular carcinomas, two carcinomas derived from follicular cells, are the most common types and occur more frequently in women. Both have a good prognosis. Medullary carcinoma derives from C-cells. Familial forms have to be searched. Anaplastic carcinoma and other malignant tumours are less frequent but have poor prognosis.
甲状腺疾病是最常见的内分泌疾病。面对甲状腺肿大或结节,医生面临的挑战是,以最高的敏感性和特异性以及最低的成本来确定哪些是良性肿瘤,哪些是需要切除的恶性肿瘤。单发结节的患病率为1%至5%。这些结节中只有2%至12%是癌症。乳头状癌和滤泡状癌这两种源自滤泡细胞的癌是最常见的类型,在女性中更为常见。两者预后都较好。髓样癌源自C细胞。必须排查家族性类型。未分化癌和其他恶性肿瘤较少见,但预后较差。