Bralet M P, Roudot-Thoraval F, Pawlotsky J M, Bastie A, Tran Van Nhieu J, Duval J, Dhumeaux D, Zafrani E S
Department of Pathology, Hospital Henri Mondor, University Paris XII, Créteil, France.
Gastroenterology. 1997 Jan;112(1):188-92. doi: 10.1016/s0016-5085(97)70234-8.
BACKGROUND & AIMS: Dual infection by hepatitis GB virus type C (GBV-C) and hepatitis C virus (HCV) is common. To assess the histopathologic impact of GBV-C infection on liver lesions, liver biopsy specimens of 105 patients chronically infected with HCV, 17 of whom (15%) were also infected with GBV-C, were reviewed.
Semiquantitative histopathologic assessment of liver lesions was performed using the Knodell's score and the METAVIR grading system.
Hepatitis activity was mild, moderate, or severe in 3 (18%), 11 (64%), and 3 (18%) patients, respectively, infected with GBV-C and HCV vs. 26 (29%), 56 (64%), and 6 (7%) patients, respectively, infected with HCV alone (no significant difference). Cirrhosis was present in 4 (24%) coinfected patients vs. 19 (22%) HCV-positive patients (no significant difference). No significant difference in fibrosis, presence of portal lymphoid aggregates, steatosis, and hemosiderosis was observed between the two groups. There was no significant difference in the evaluation of each item of the Knodell's score.
This detailed histopathologic evaluation of GBV-C infection in chronic hepatitis C shows that GBV-C infection does not affect histopathologic severity and characteristics of chronic hepatitis C, thus suggesting a minor role of GBV-C infection in liver disease.
丙型GB病毒（GBV-C）与丙型肝炎病毒（HCV）双重感染很常见。为评估GBV-C感染对肝脏病变的组织病理学影响，我们回顾了105例慢性HCV感染患者的肝活检标本，其中17例（15%）同时感染了GBV-C。
采用Knodell评分和METAVIR分级系统对肝脏病变进行半定量组织病理学评估。
GBV-C和HCV双重感染的患者中，肝炎活动度为轻度、中度或重度的分别有3例（18%）、11例（64%）和3例（18%），而单独感染HCV的患者中分别为26例（29%）、56例（64%）和6例（7%）（无显著差异）。合并感染患者中有4例（24%）出现肝硬化，HCV阳性患者中有19例（22%）出现肝硬化（无显著差异）。两组在纤维化、门管区淋巴滤泡聚集、脂肪变性和含铁血黄素沉着方面无显著差异。Knodell评分各项评估结果无显著差异。
对慢性丙型肝炎患者GBV-C感染进行的详细组织病理学评估表明，GBV-C感染不影响慢性丙型肝炎的组织病理学严重程度和特征，因此提示GBV-C感染在肝脏疾病中作用较小。
