Shaw T J, Murphy C R
Department of Anatomy and Histology, University of Sydney, NSW, Australia.
Cell Biol Int. 1996 Nov;20(11):717-22. doi: 10.1006/cbir.1996.0093.
Intra-uterine injection of the lectin Concanavalin A (ConA) on day 5 of pseudopregnancy induced a rapid and persistent infiltration of leucocytes into the rat uterine stroma. Although the infiltration of leucocytes was seen along the entire length of the uterine horn, areas of stromal oedema, indicative of decidualization (as indicated by a positive Pontamine Sky Blue reaction), were only associated with regions in which leucocytes had crossed the uterine epithelium and were present in the uterine lumen. Ultrastructural evaluation of the interaction of the luminal leucocytes with the apical surface of the uterine epithelium appeared strikingly similar to that of the blastocyst and the uterine epithelium during normal implantation. It is proposed that leucocytes, induced by ConA, may initiate a decidual response in a manner analogous to that of the blastocyst through surface epithelial interaction.
在假孕第5天向子宫内注射凝集素伴刀豆球蛋白A（ConA）可诱导白细胞迅速且持续地浸润到大鼠子宫基质中。尽管在整个子宫角都可见白细胞浸润，但基质水肿区域（以阳性滂胺天蓝反应表明为蜕膜化）仅与白细胞穿过子宫上皮并存在于子宫腔内的区域相关。对腔内白细胞与子宫上皮顶端表面相互作用的超微结构评估显示，其与正常着床期间囊胚和子宫上皮的相互作用惊人地相似。有人提出，ConA诱导的白细胞可能通过与表面上皮的相互作用，以类似于囊胚的方式引发蜕膜反应。
