Adu F D, Adedeji A A, Esan J S, Odusanya O G
Department of Virology, College of Medicine, University of Ibadan, Nigeria.
Public Health. 1996 Nov;110(6):325-30. doi: 10.1016/s0033-3506(96)80003-5.
This study was carried out in the states of Lagos, Oyo, Osun, Nigeria and was designed to assess the efficiency of the cold chain and the potency of the vaccines from the National Cold Store through to the vaccination centres. Storage equipment was inspected and oral polio, measles and yellow fever vaccines were tested for potency. All 27 centres studied had adequately trained staff and storage was shown to be adequate at the National and State Cold Store Level. However, vaccines were adversely affected at the local Government Area Cold Store and Vaccination Centre Levels. Losses of potency of vaccines were shown: loss of titre of oral polio and yellow fever vaccine (0.03-0.9 log) was less than that of the measles vaccines (0.1-2.7 log). This was ascribed to thawing and refreezing due to equipment failure, to intermittent power supply in the absence of standby generators and mishandling of vaccines in the vaccine centres. This study revealed inadequacies at the Local Government Area and Vaccination Centre level. The cold chain should be examined in the remaining states of Nigeria and the inadequacies corrected.
本研究在尼日利亚的拉各斯州、奥约州、奥孙州开展，旨在评估从国家冷藏库到疫苗接种中心的冷链效率以及疫苗效力。对储存设备进行了检查，并对口服脊髓灰质炎疫苗、麻疹疫苗和黄热病疫苗的效力进行了检测。所研究的全部27个中心都有经过充分培训的工作人员，且国家和州级冷藏库的储存条件显示是充足的。然而，疫苗在地方政府辖区冷藏库和疫苗接种中心层面受到了不利影响。研究表明存在疫苗效力损失的情况：口服脊髓灰质炎疫苗和黄热病疫苗的滴度损失（0.03 - 0.9对数）低于麻疹疫苗（0.1 - 2.7对数）。这归因于设备故障导致的解冻和重新冷冻、在没有备用发电机的情况下间歇性停电以及疫苗接种中心对疫苗的不当处理。本研究揭示了地方政府辖区和疫苗接种中心层面存在的不足。应在尼日利亚其余各州检查冷链情况并纠正这些不足。
