Parry H, Cohen S, Schlarb J E, Tyrrell D A, Fisher A, Russell M A, Jarvis M J
Department of Haematology, Salisbury District Hospital, England.
Am J Clin Pathol. 1997 Jan;107(1):64-7. doi: 10.1093/ajcp/107.1.64.
Blood was collected from 684 healthy volunteers and examined for total and differential white blood cell (WBC) counts. A subgroup also was tested for numbers of T cells, B cells, and CD4 and CD8 subsets. Smoking status and alcohol consumption were determined by means of questionnaire, and smoking status was verified with serum cotinine concentration. High smoking rate was associated with increases in all counts. Former smokers abstinent less than 5 years still demonstrated elevated counts, whereas those abstinent more than 5 years had WBC counts comparable to those in persons who were never smokers. Compared with levels in those who had never smoked, total WBC counts were 27% higher in current smokers and 14% higher in former smokers who were abstinent for less than 5 years. Lymphocyte counts were 9% higher in those consuming more than one alcoholic drink per day than in those consuming less alcohol, but drinking was not associated with other cell populations.
从684名健康志愿者身上采集血液，检测白细胞（WBC）总数及分类计数。还对一个亚组进行了T细胞、B细胞以及CD4和CD8亚群数量的检测。通过问卷调查确定吸烟状况和饮酒情况，并通过血清可替宁浓度验证吸烟状况。高吸烟率与所有细胞计数增加有关。戒烟时间少于5年的既往吸烟者细胞计数仍偏高，而戒烟超过5年者的白细胞计数与从不吸烟者相当。与从不吸烟者相比，当前吸烟者的白细胞总数高27%，戒烟时间少于5年的既往吸烟者高14%。每天饮酒超过一杯者的淋巴细胞计数比饮酒较少者高9%，但饮酒与其他细胞群体无关。
