Department of Biochemistry and Medical Genetics, School of Health Sciences in Katowice, Medical University of Silesia, Medyków Street 18, 40-752 Katowice, Poland.
1st Department of Cardiac Surgery/2nd Department of Cardiology, American Heart of Poland, S. A. Armii Krajowej Street 101, 43-316 Bielsko-Biala, Poland.
Dis Markers. 2017;2017:1540949. doi: 10.1155/2017/1540949. Epub 2017 Sep 29.
Paraoxonase-1 (PON1) is the antioxidant marker of high-density lipoproteins protecting against atherosclerosis and coronary artery disease (CAD) phenotype. The purpose of the present study was to determine whether the gene rs854560 polymorphism (163T>A) is associated with CAD in Polish population. rs854560 was genotyped in 494 subjects: 248 patients with premature CAD and 246 blood donors as a control. We found that the risk of CAD was significantly higher in TT homozygotes than in A allele carriers (OR = 1.87, = 0.041). The synergistic effect between the TT genotype and cigarette smoking was observed (SIM = 9.81; SI = 14.70). The relative increase in risk from interaction between factors was over 37 (RERI = 36.13). The polymorphism did not modulate the risk of CAD in response to exposure to other traditional risk factors. In conclusion, the rs854560 polymorphism may modulate the risk of CAD in response to cigarette smoking in Polish population. Carriers of TT genotype seem to be particularly at risk of CAD, when exposed to cigarette smoking.
对氧磷酶 1（PON1）是高密度脂蛋白的抗氧化标志物，可预防动脉粥样硬化和冠心病（CAD）表型。本研究的目的是确定波兰人群中基因 rs854560 多态性（163T>A）是否与 CAD 相关。在 494 名受试者中进行了 rs854560 基因分型：248 名早发性 CAD 患者和 246 名献血者作为对照。我们发现 TT 纯合子发生 CAD 的风险明显高于 A 等位基因携带者（OR=1.87，=0.041）。还观察到 TT 基因型与吸烟之间存在协同作用（SIM=9.81；SI=14.70）。来自因素之间相互作用的风险相对增加超过 37（RERI=36.13）。该多态性并未调节其他传统危险因素暴露下 CAD 的风险。总之，rs854560 多态性可能会调节波兰人群中吸烟对 CAD 风险的影响。当暴露于吸烟时，TT 基因型携带者似乎特别容易患 CAD。
