Martin M V, Yates J, Hitchcock C A
Department of Clinical Dental Sciences, University of Liverpool, United Kingdom.
Antimicrob Agents Chemother. 1997 Jan;41(1):13-6. doi: 10.1128/AAC.41.1.13.
Left-sided Aspergillus fumigatus endocarditis was established in the guinea pig heart by catheterization and inoculation with conidia via a tributary of the femoral vein. This animal model was used to compare the efficacy of the triazole antifungal agents voriconazole (UK-109,496) and itraconazole. In the prophylaxis experiments, voriconazole at a dosage of 10 mg/kg of body weight given intraperitoneally twice daily prevented A. fumigatus endocarditis in all but 1 animal (11 of 12 animals were cured). Itraconazole did not prevent Aspergillus endocarditis when it was given at the same dosage and by the same route (0 to 12 animals were cured). In the treatment experiments with 10 animals per group, voriconazole at 10, 7.5 and 5 mg/kg given orally twice daily for 7 days produced cure rates of 100, 70 and 0%, respectively. In contrast, itraconazole at 10 mg/kg given orally twice daily did not cure A. fumigatus endocarditis in the guinea pig. It is concluded that voriconazole is highly efficacious in the prevention and treatment of Aspergillus endocarditis in the guinea pig and is superior to itraconazole in these respects.
通过经股静脉分支插管并接种分生孢子，在豚鼠心脏中建立了左侧烟曲霉菌性心内膜炎。该动物模型用于比较三唑类抗真菌药物伏立康唑（UK-109,496）和伊曲康唑的疗效。在预防实验中，以10mg/kg体重的剂量腹腔内注射伏立康唑，每日两次，除1只动物外，所有动物均预防了烟曲霉菌性心内膜炎（12只动物中有11只治愈）。当以相同剂量和相同途径给予伊曲康唑时，它不能预防曲霉菌性心内膜炎（0至12只动物治愈）。在每组10只动物的治疗实验中，口服伏立康唑，剂量分别为10mg/kg、7.5mg/kg和5mg/kg，每日两次，持续7天，治愈率分别为100%、70%和0%。相比之下，口服伊曲康唑，剂量为10mg/kg，每日两次，不能治愈豚鼠的烟曲霉菌性心内膜炎。结论是伏立康唑在预防和治疗豚鼠曲霉菌性心内膜炎方面非常有效，在这些方面优于伊曲康唑。
