巴西患者侵袭性曲霉病的烟曲霉分离株中尚未出现三唑类耐药现象。
Triazole Resistance Is Still Not Emerging in Aspergillus fumigatus Isolates Causing Invasive Aspergillosis in Brazilian Patients.
机构信息
Laboratório Especial de Micologia, Disciplina de Infectologia, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, São Paulo, Brazil.
Departamento de Patologia, Centro de Investigações em Micologia Médica (CIMM), Universidade Federal do Espírito Santo, Vitória, Espírito Santo, Brazil.
出版信息
Antimicrob Agents Chemother. 2017 Oct 24;61(11). doi: 10.1128/AAC.00608-17. Print 2017 Nov.
Abstract
azole resistance has emerged as a global health problem. We evaluated the antifungal susceptibility of 221 clinical isolates according to CLSI guidelines. Sixty-one isolates exhibiting MICs at the epidemiological cutoff value (ECV) for itraconazole or above the ECV for any triazole were checked for mutations. No mutations were documented, even for the isolates (1.8%) with high voriconazole MICs, indicating that triazoles may be used safely to treat aspergillosis in Brazil.
摘要
唑类耐药性已经成为一个全球性的健康问题。我们根据 CLSI 指南评估了 221 株临床分离株的抗真菌药敏性。对 61 株 MIC 值达到伊曲康唑的流行病学 cutoff 值（ECV）或任何三唑类药物的 ECV 以上的分离株进行了突变检测。即使是那些高伏立康唑 MIC 值的分离株（1.8%）也没有记录到突变，这表明三唑类药物可安全用于巴西的曲霉菌病治疗。
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