Hutchings D E, Hamowy A S, Williams E M, Zmitrovich A C
New York State Psychiatric Institute, Department of Developmental Psychobiology, NY 10032, USA.
Pharmacol Biochem Behav. 1996 Dec;55(4):607-13. doi: 10.1016/s0091-3057(96)00287-0.
Three doses of buprenorphine (BUP) were administered by osmotic minipump from day 8 of gestation through parturition. In addition to 0.3, 1.0, and 3.0 mg/kg/day of BUP, a vehicle control group received sterile water via minipump and a nontreated control group was left undisturbed during pregnancy. All treated and control litters were fostered at birth to untreated dams. BUP produced a dose response reduction in maternal water intake and reduced maternal weight gain among the two high dose groups; resorptions and birthweight were unaffected. BUP increased perinatal mortality in the two high dose groups compared with the vehicle controls and produced inconsistent effects on postnatal growth. To examine the effects of BUP on the rest-activity cycle of the offspring, groups of 3 littermates from each of the treated and control groups were tested for an 8 h observation period on electronic activity monitors at 22 and 30 days of age. Unlike previous effects described for prenatally administered methadone, a disruption in the rest-activity cycle was not observed for any of the BUP treated groups.
从妊娠第8天至分娩期间，通过渗透微型泵给予三剂丁丙诺啡（BUP）。除了每日给予0.3、1.0和3.0mg/kg的BUP外，一个赋形剂对照组通过微型泵接受无菌水，一个未处理对照组在妊娠期间不做处理。所有处理组和对照组的幼崽在出生时都寄养给未处理的母鼠。BUP在两个高剂量组中导致母体饮水量呈剂量反应性减少，并使母体体重增加减少；吸收和出生体重未受影响。与赋形剂对照组相比，BUP在两个高剂量组中增加了围产期死亡率，并对出生后生长产生了不一致的影响。为了研究BUP对后代静息-活动周期的影响，在22日龄和30日龄时，对来自每个处理组和对照组的3只同窝幼崽进行分组，在电子活动监测仪上进行8小时的观察期测试。与先前描述的产前给予美沙酮的效果不同，未观察到任何BUP处理组的静息-活动周期受到干扰。
