Hutchings D E, Gamagaris Z, Miller N, Fico T A
New York State Psychiatric Institute, Department of Developmental Psychobiology, New York 10032.
Neurotoxicol Teratol. 1989 Jul-Aug;11(4):353-6. doi: 10.1016/0892-0362(89)90006-8.
Either 15 or 50 mg/kg of delta-9-tetrahydrocannabinol (delta-9-THC) was administered from Day 2 through Day 22 of gestation. Pair-fed (0 mg/kg) and nontreated groups served as controls and all treated and control litters were fostered at birth to untreated dams. To examine whether delta-9-THC produces effects on the rest-activity cycle of the offspring, groups of 3 littermates from each of the treated and control groups were tested for an 8 hr observation period on electronic activity monitors at 17, 22 and 30 days of age. Whereas all treated and control groups showed age-dependent changes in activity, neither activity level nor the rest-activity pattern were affected by delta-9-THC. These findings are discussed in relation to neurobehavioral studies of activity changes following prenatal exposure to cannabis.
在妊娠第2天至第22天期间，给予15或50毫克/千克的δ-9-四氢大麻酚（δ-9-THC）。配对喂食组（0毫克/千克）和未处理组作为对照，所有处理组和对照组的幼崽在出生时都寄养给未处理的母鼠。为了研究δ-9-THC是否对后代的休息-活动周期产生影响，在17、22和30日龄时，对来自每个处理组和对照组的3只同窝幼崽进行分组，在电子活动监测器上进行8小时的观察期测试。虽然所有处理组和对照组的活动都呈现出年龄依赖性变化，但δ-9-THC既不影响活动水平，也不影响休息-活动模式。结合产前接触大麻后活动变化的神经行为研究对这些发现进行了讨论。
