Teraki Y, Imanishi K, Shiohara T
Department of Dermatology, Kyorin University School of Medicine, Tokyo, Japan.
Acta Derm Venereol. 1996 Nov;76(6):421-3. doi: 10.2340/0001555576421423.
Recent studies have suggested that cytokines play a critical role in the pathophysiology of alopecia areata; however, no information is available regarding the difference in cytokine profiles in these patients. Serum levels of cytokines, including interferon gamma (IFN-gamma), tumor necrosis factor alpha, interleukin 1 alpha (IL-1 alpha), IL-2, IL-4, and IL-6, were measured using radioimmunoassay or enzyme-linked immunosorbent assay techniques in patients with the localized form and the extensive form (alopecia universalis). The serum levels of IL-1 alpha and IL-4 were significantly elevated in patients with the localized form. In contrast, the serum levels of IFN-gamma and IL-2 were significantly elevated in patients with the extensive form. These results indicate that immune responses in the localized form and the extensive form of alopecia areata are regulated by Th2 cytokines and Th1 cytokines, respectively.
近期研究表明，细胞因子在斑秃的病理生理学中起关键作用；然而，关于这些患者细胞因子谱的差异尚无相关信息。采用放射免疫测定法或酶联免疫吸附测定技术，对局限性斑秃和广泛性斑秃（全秃）患者血清中的细胞因子水平进行了检测，这些细胞因子包括γ干扰素（IFN-γ）、肿瘤坏死因子α、白细胞介素1α（IL-1α）、IL-2、IL-4和IL-6。局限性斑秃患者血清中IL-1α和IL-4水平显著升高。相比之下，广泛性斑秃患者血清中IFN-γ和IL-2水平显著升高。这些结果表明，局限性斑秃和广泛性斑秃的免疫反应分别由Th2细胞因子和Th1细胞因子调节。
