Thompson K S, Reyes C V, Jensen J, Gattuso P, Sacks R
Cytology Section, Veterans Affairs Hospital, Hines, IL, USA.
Diagn Cytopathol. 1996 Nov;15(4):334-7. doi: 10.1002/(SICI)1097-0339(199611)15:4<334::AID-DC16>3.0.CO;2-P.
Synovial metastases are a rare occurrence. Only 28 cases have been reported in the literature, 10 of which were diagnosed by fluid cytologic evaluation. We discuss 2 additional cases in which the diagnosis was made by fine-needle aspiration cytologic investigation. The first case is of a 47-yr-old man with small-cell carcinoma of the lung metastatic to the right knee joint; the second is of a 71-yr-old man with non-Hodgkin's mixed-cell nodular lymphoma also involving the right knee joint. The clinical features of these cases are similar to previously published instances of secondary synovial tumor, namely in regard to sex distribution (14 male and 16 female patients), age range (13-96 yr, mean 59 yr), and histologic types (adenocarcinoma, 13 cases; squamous-cell carcinoma, 4; lymphoma, 3; renal clear-cell carcinoma, 3; unknown origin, 2; rhabdomyosarcoma, 1; melanoma, 1; chordoma, 1; pulmonary clear-cell carcinoma, 1; and Ewing's sarcoma, 1). The condition usually has poor prognosis, with average patient survival of < 5 mo.
滑膜转移瘤较为罕见。文献中仅报道了28例，其中10例通过液体细胞学评估确诊。我们讨论另外2例通过细针穿刺细胞学检查确诊的病例。第一例是一名47岁男性，患有肺小细胞癌，转移至右膝关节；第二例是一名71岁男性，患有非霍奇金混合细胞结节性淋巴瘤，也累及右膝关节。这些病例的临床特征与先前发表的继发性滑膜肿瘤病例相似，即在性别分布（14例男性和16例女性患者）、年龄范围（13 - 96岁，平均59岁）以及组织学类型方面（腺癌13例；鳞状细胞癌4例；淋巴瘤3例；肾透明细胞癌3例；来源不明2例；横纹肌肉瘤1例；黑色素瘤1例；脊索瘤1例；肺透明细胞癌1例；尤因肉瘤1例）。这种情况通常预后较差，患者平均生存期<5个月。
