Kvaerner K J, Nafstad P, Hagen J A, Mair I W, Jaakkola J J
Section of Epidemiology, National Institute of Public Health, Oslo, Norway.
Arch Dis Child. 1996 Oct;75(4):338-41. doi: 10.1136/adc.75.4.338.
To assess the relation between early acute otitis media and exposure to respiratory pathogens mediated by siblings and other children, a prospective cohort of 3754 Norwegian children born in 1992-3 was followed up from birth to 12 months. Of these, 25% had one or more episodes of acute otitis media during the first year. Results from multiple logistic regression analysis adjusted for confounding showed that siblings' attendance at daycare is the most important risk factor for early acute otitis media (adjusted odds ratio, ORadj = 1.9). The total number of children in the daycare setting is another determinant for early acute otitis media (ORadj = 2.0 in groups of four or more other children and ORadj = 1.3 in groups of one to three other children, as compared to those who are cared for alone). Having siblings in daycare outside the home and the number of children in the daycare setting are the most important determinants for early acute otitis media.
为评估1992年至1993年出生的3754名挪威儿童从出生到12个月期间，早期急性中耳炎与同胞及其他儿童介导的呼吸道病原体暴露之间的关系，进行了一项前瞻性队列研究。其中，25%的儿童在第一年发生过一次或多次急性中耳炎。经混杂因素调整后的多因素logistic回归分析结果显示，同胞入托是早期急性中耳炎最重要的危险因素（调整后的优势比，ORadj = 1.9）。日托机构中的儿童总数是早期急性中耳炎的另一个决定因素（与独自照料的儿童相比，在有四个或更多其他儿童的组中ORadj = 2.0，在有一至三个其他儿童的组中ORadj = 1.3）。家中同胞在日托机构以及日托机构中的儿童数量是早期急性中耳炎最重要的决定因素。
