白藜芦醇的癌症化学预防活性，一种源自葡萄的天然产物。

Cancer chemopreventive activity of resveratrol, a natural product derived from grapes.

作者信息

Jang M, Cai L, Udeani G O, Slowing K V, Thomas C F, Beecher C W, Fong H H, Farnsworth N R, Kinghorn A D, Mehta R G, Moon R C, Pezzuto J M

机构信息

Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, Chicago, IL 60612, USA.

出版信息

Science. 1997 Jan 10;275(5297):218-20. doi: 10.1126/science.275.5297.218.

DOI:10.1126/science.275.5297.218

PMID:8985016

Abstract

Resveratrol, a phytoalexin found in grapes and other food products, was purified and shown to have cancer chemopreventive activity in assays representing three major stages of carcinogenesis. Resveratrol was found to act as an antioxidant and antimutagen and to induce phase II drug-metabolizing enzymes (anti-initiation activity); it mediated anti-inflammatory effects and inhibited cyclooxygenase and hydroperoxidase functions (antipromotion activity); and it induced human promyelocytic leukemia cell differentiation (antiprogression activity). In addition, it inhibited the development of preneoplastic lesions in carcinogen-treated mouse mammary glands in culture and inhibited tumorigenesis in a mouse skin cancer model. These data suggest that resveratrol, a common constituent of the human diet, merits investigation as a potential cancer chemopreventive agent in humans.

摘要

白藜芦醇是一种在葡萄和其他食品中发现的植保素，经过纯化后，在代表致癌作用三个主要阶段的试验中显示出癌症化学预防活性。白藜芦醇被发现具有抗氧化和抗诱变作用，并能诱导II期药物代谢酶（抗启动活性）；它介导抗炎作用，抑制环氧化酶和氢过氧化物酶功能（抗促进活性）；并诱导人早幼粒细胞白血病细胞分化（抗进展活性）。此外，它抑制了致癌物处理的小鼠乳腺中癌前病变的发展，并在小鼠皮肤癌模型中抑制了肿瘤发生。这些数据表明，白藜芦醇作为人类饮食中的常见成分，值得作为一种潜在的人类癌症化学预防剂进行研究。