Clark A S, Fast A S
Department of Psychology, Dartmouth College, Hanover, New Hampshire 03755, USA.
Behav Neurosci. 1996 Dec;110(6):1478-86. doi: 10.1037//0735-7044.110.6.1478.
In a series of 3 experiments, adult male Long-Evans rats were castrated and treated with 1 of 3 different anabolic-androgenic steroid (AAS) compounds (17 alpha-methyltestosterone, methandrostenolone, or nandrolone decanoate) for 6 weeks. In each experiment, subjects received daily injections of a high, medium, or low dose of AAS or the oil vehicle. The AAS effects on body weight in gonadectomized male rats were modest, and no effects on locomotor activity were observed. The AAS compounds administered at doses comparable with human abuse levels were not equipotent in maintaining male sexual behavior patterns (nandrolone decanoate > methandrostenolone > 17 alpha-methyltestosterone). In addition, the behavioral actions of AAS compounds did not parallel stimulation of sexual accessory glands. The authors reported that this study is the first to quantify the dose-response characteristics of individual AAS compounds with regard to these behavioral and endocrine measures.
在一系列3个实验中，成年雄性Long-Evans大鼠被阉割，并使用3种不同的合成代谢雄激素类固醇（AAS）化合物（17α-甲基睾酮、大力补或癸酸诺龙）中的一种进行为期6周的治疗。在每个实验中，受试动物每日接受高、中或低剂量的AAS或油性赋形剂注射。AAS对去势雄性大鼠体重的影响较小，且未观察到对运动活动的影响。以与人类滥用水平相当的剂量施用的AAS化合物在维持雄性性行为模式方面并非等效（癸酸诺龙>大力补>17α-甲基睾酮）。此外，AAS化合物的行为作用与性附属腺的刺激并不平行。作者报告称，这项研究首次量化了个体AAS化合物在这些行为和内分泌指标方面的剂量反应特征。
