Blasberg M E, Langan C J, Clark A S
Department of Psychology, Dartmouth College, Hanover, NH 03755, USA.
Physiol Behav. 1997 Feb;61(2):265-72. doi: 10.1016/s0031-9384(96)00409-x.
In a series of four separate experiments, the effects of anabolic-androgenic steroid (AAS) compounds on the estrous cycle of adult Long-Evans rats were examined. Sexual receptivity, vaginal cytology, and body weight were monitored throughout a 2-week baseline, AAS treatment, and recovery periods. In Experiments 1-3, subjects were administered 17 alpha-methyltestosterone, methandrostenolone, or nandrolone decanoate at doses selected to mimic the human abuse levels of each compound. In these studies, the highest doses of 17 alpha-methyltestosterone (7.5 mg/kg) and nandrolone decanoate (5.6 mg/kg) disrupted behavioral and vaginal cyclicity, whereas the highest dose of methandrostenolone (3.75 mg/kg) appeared to have slightly less robust effects. To compare effects on estrous cyclicity across AAS compounds, subjects in Experiment 4 received a single high dose (7.5 mg/kg) of each compound for 2 weeks. At this dose, all AAS compounds interfered with vaginal cyclicity, although effects on behavioral cyclicity and uterine weight were not uniform. Across all 4 experiments, AAS effects on body weight were minimal. The short-term administration of AAS compounds at levels commonly used by humans disrupts female neuroendocrine function in a dose-dependent manner.
在一系列四项独立实验中，研究了合成代谢雄激素类固醇（AAS）化合物对成年Long-Evans大鼠发情周期的影响。在为期2周的基线期、AAS治疗期和恢复期，对性接受能力、阴道细胞学和体重进行了监测。在实验1-3中，给实验对象施用17α-甲基睾酮、大力补或癸酸诺龙，所选剂量模拟了每种化合物的人类滥用水平。在这些研究中，17α-甲基睾酮的最高剂量（7.5毫克/千克）和癸酸诺龙的最高剂量（5.6毫克/千克）破坏了行为和阴道周期，而大力补的最高剂量（3.75毫克/千克）的影响似乎略小。为了比较不同AAS化合物对发情周期的影响，实验4中的实验对象接受了每种化合物的单一高剂量（7.5毫克/千克），持续2周。在此剂量下，所有AAS化合物均干扰了阴道周期，尽管对行为周期和子宫重量的影响并不一致。在所有4项实验中，AAS对体重的影响最小。以人类常用水平短期施用AAS化合物会以剂量依赖的方式破坏雌性神经内分泌功能。
