Ter-Grigorov V S, Krifuks O, Liubashevsky E, Nyska A, Trainin Z, Toder V
Department of Immunology and Pathology, Kimron Veterinary Institute, Bet-Dagan, Israel.
Nat Med. 1997 Jan;3(1):37-41. doi: 10.1038/nm0197-37.
The search for a suitable and reliable animal model for human AIDS that is easy to use on a large scale continues. Here we describe a new condition in mice that closely resembles human AIDS, namely, chronic lymphoproliferation with dramatic depletion of CD4-positive cells, progressive impairment of the immune responses, and Kaposi's sarcoma-like tumors or terminal B-lymphomas. The AIDS-like disease was primarily induced by mating BALB/c female mice to C57BL/6 males during a 1-year period (7-10 allogeneic pregnancies) followed by immunization with paternal lymphocytes. The disease is sexually and vertically transmissible, transferrable by cell-free plasma and is associated with autoimmune reactions to major histocompatibility complex antigens and CD4 cells. We hope that this becomes a model for studying the mechanisms of AIDS immunopathogenesis and immune-based treatment approaches.
对一种适用于人类艾滋病、易于大规模使用的合适且可靠的动物模型的探索仍在继续。在此，我们描述了一种小鼠的新病症，它与人类艾滋病极为相似，即慢性淋巴细胞增殖伴CD4阳性细胞显著耗竭、免疫反应进行性受损以及卡波西肉瘤样肿瘤或晚期B细胞淋巴瘤。这种类似艾滋病的疾病主要是通过在1年时间内（7 - 10次同种异体妊娠）将BALB/c雌性小鼠与C57BL/6雄性小鼠交配，随后用父本淋巴细胞进行免疫诱导产生的。该疾病具有性传播和垂直传播的特性，可通过无细胞血浆进行转移，并且与针对主要组织相容性复合体抗原和CD4细胞的自身免疫反应有关。我们希望这能成为研究艾滋病免疫发病机制和基于免疫的治疗方法的模型。
