Terman D, Bose A, Kopell N
Department of Mathematics, Boston University, MA 02215, USA.
Proc Natl Acad Sci U S A. 1996 Dec 24;93(26):15417-22. doi: 10.1073/pnas.93.26.15417.
Thalamic reticularis, thalamocortical, and cortical cells participate in the 7-14-hz spindling rhythm of early sleep and the slower delta rhythms of deeper sleep, with different firing patterns. In this case study, showing the interactions of intrinsic and synaptic properties, a change in the conductance of one kind of cell effectively rewires the thalamocortical circuit, leading to the transition from the spindling to the delta rhythm. The two rhythms make different uses of the fast (GABAA) and slow (GABAB) inhibition generated by the thalamic reticularis cells.
丘脑网状核、丘脑皮质和皮质细胞以不同的放电模式参与早期睡眠的7-14赫兹纺锤波节律和深度睡眠时较慢的δ节律。在这个展示内在特性和突触特性相互作用的案例研究中,一种细胞电导的变化有效地重新连接了丘脑皮质回路,导致从纺锤波节律向δ节律的转变。这两种节律对丘脑网状核细胞产生的快速(GABAA)和慢速(GABAB)抑制作用有不同的利用方式。