Awan S, Davenport M, Portmann B, Howard E R
Department of Paediatric Surgery, King's College Hospital, Denmark Hill, London, England.
J Pediatr Surg. 1996 Dec;31(12):1729-32. doi: 10.1016/s0022-3468(96)90065-2.
The clinico-pathological features of four cases of pediatric hepatic angiosarcomas are described. One case was initially diagnosed in infancy and underwent resection of a left-sided benign hemangioendothelioma of the liver. Further resection of a lesion in the right liver was followed by malignant transformation. Primary hepatic resection of the tumor was not possible in three other cases, and all received courses of chemotherapy without significant tumor shrinkage. One child underwent liver transplantation but died 4 months later of immunosuppression complications. The remaining three children died of disseminated malignancy. Histological verification of malignancy was difficult in three cases in which there was discrepancy between the rapid growth of the liver tumor and the microscopic features of benign hemangioendothelioma.
本文描述了4例儿童肝脏血管肉瘤的临床病理特征。1例在婴儿期初诊，接受了左侧肝脏良性血管内皮瘤切除术。右肝病变进一步切除后发生恶变。其他3例无法进行肿瘤的一期肝切除，均接受了化疗，但肿瘤未见明显缩小。1例患儿接受了肝移植，但4个月后死于免疫抑制并发症。其余3例患儿死于播散性恶性肿瘤。在3例肝脏肿瘤快速生长但镜下特征为良性血管内皮瘤的病例中，恶性肿瘤的组织学确诊存在困难。
