Blissard G W
Boyce Thompson Institute, Cornell University, Ithaca, NY 14853-1801, USA.
Cytotechnology. 1996;20(1-3):73-93. doi: 10.1007/BF00350390.
Baculovirus interactions with host cells range from the physical interactions that occur during viral binding and entry, to the complex and subtle mechanisms that regulate host gene expression and modify and regulate cellular and organismal physiology and defenses. Fundamental studies of baculovirus biochemistry and molecular biology have yielded many interesting and important discoveries on the mechanisms of these virus-host interactions. Information from such studies has also resulted in exciting new strategies for environmentally sound insect pest control, and in the development and improvement of a valuable eukaryotic expression vector system. In addition a number of important and valuable model biological systems have emerged from studies of baculoviruses. These include robust systems for studies of eukaryotic transcription, viral DNA replication, membrane fusion, and apoptosis. Because functions have been identified for only a small number of baculovirus genes, we can expect many exciting new discoveries in the future and an unfolding of the complex and intricate relationship between baculoviruses and insect cells.
杆状病毒与宿主细胞的相互作用范围广泛，从病毒结合和进入过程中发生的物理相互作用，到调节宿主基因表达、改变和调节细胞及机体生理与防御的复杂而微妙的机制。杆状病毒生物化学和分子生物学的基础研究在这些病毒 - 宿主相互作用机制方面取得了许多有趣且重要的发现。这些研究所得信息还催生了环保型害虫控制的激动人心的新策略，以及有价值的真核表达载体系统的开发与改进。此外，杆状病毒研究还涌现出了一些重要且有价值的模型生物系统。这些系统包括用于研究真核转录、病毒DNA复制、膜融合和细胞凋亡的强大系统。由于仅鉴定出少数杆状病毒基因的功能，我们有望在未来获得许多令人兴奋的新发现，并揭示杆状病毒与昆虫细胞之间复杂而精细的关系。
