Panicek D M, Gatsonis C, Rosenthal D I, Seeger L L, Huvos A G, Moore S G, Caudry D J, Palmer W E, McNeil B J
Department of Radiology, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA.
Radiology. 1997 Jan;202(1):237-46. doi: 10.1148/radiology.202.1.8988217.
To assess the relative accuracies of computed tomography (CT) and magnetic resonance (MR) imaging in the local staging of primary malignant bone and soft-tissue tumors.
At four institutions, 367 eligible patients (aged 6-89 years) with malignant bone or soft-tissue neoplasms in selected anatomic sites were enrolled. Patients underwent both CT and MR imaging within 4 weeks before surgery. In each patient, CT scans were interpreted independently by two radiologists and MR images by two other radiologists at the enrolling institution. The CT and MR images were then interpreted together by two of those radiologists and subsequently reread at the other institutions. Imaging and histopathologic findings were compared and were supplemented when needed with surgical findings. Receiver operating characteristic curve analysis and descriptive statistical analysis were performed.
Cases were analyzable in 316 patients: 183 had primary bone tumors; 133 had primary soft-tissue tumors. There was no statistically significant difference between CT and MR imaging in determining tumor involvement of muscle, bone, joints, or neurovascular structures. The combined interpretation of CT and MR images did not statistically significantly improve accuracy. Interreader variability was similar for both modalities.
CT and MR imaging are equally accurate in the local staging of malignant bone and soft-tissue neoplasms in the specific anatomic sites studied.
评估计算机断层扫描（CT）和磁共振成像（MR）在原发性恶性骨肿瘤和软组织肿瘤局部分期中的相对准确性。
在四家机构，纳入了367例符合条件的患者（年龄6 - 89岁），这些患者在选定的解剖部位患有恶性骨或软组织肿瘤。患者在手术前4周内均接受了CT和MR成像检查。在每家纳入机构，由两名放射科医生独立解读每位患者的CT扫描图像，另外两名放射科医生解读MR图像。然后由其中两名放射科医生共同解读CT和MR图像，随后在其他机构进行再次解读。将影像学和组织病理学结果进行比较，必要时补充手术结果。进行了受试者操作特征曲线分析和描述性统计分析。
316例患者的病例可进行分析：183例患有原发性骨肿瘤；133例患有原发性软组织肿瘤。在确定肿瘤对肌肉、骨骼、关节或神经血管结构的累及方面，CT和MR成像之间无统计学显著差异。CT和MR图像的联合解读在统计学上并未显著提高准确性。两种检查方法的阅片者间变异性相似。
在所研究的特定解剖部位的恶性骨肿瘤和软组织肿瘤局部分期中，CT和MR成像的准确性相当。
