Mhalu F S, Matre R
Department of Microbiology and Immunology, Muhimbill Medical Centre, University of Dar es Salaam, Tanzania.
East Afr Med J. 1996 Sep;73(9):583-5.
Investigations were performed on sera from blood donors, pregnant women, patients with polyarthritis and from patients with clinical suspicion of syphilis in Dar es Salaam using Borrelia burgdorferi (Bb) flagellar antigen in a second generation ELISA test from DAKO A/S, Denmark, for specific IgM or IgG antibodies. An IgM and or IgG seropositivity rate of 30/100 (30%), 19/50 (7.2%), 10/20 (50%) and 11/20 (55%) was found in sera from the respective groups. These results compare with a Bb seroprevalence rate of 4/100 (4%), 1/52 (2%) and 363/5024 (7.2%) in blood donors, in pregnant women and in patients investigated serologically for Lyme borreliosis (Lb) respectively in Bergen, Norway, where cases of Lb are detected regularly. The high prevalence of antibodies to Bb flagellar antigen in Dar es Salaam, Tanzania where clinical conditions including erythema migrans, arthritis, mycocarditis and CNS diseases as well as tickbites are found call for further clinical, entomological and laboratory investigations.
使用丹麦达科公司（DAKO A/S）生产的第二代酶联免疫吸附测定（ELISA）检测中伯氏疏螺旋体（Bb）鞭毛抗原，对达累斯萨拉姆地区献血者、孕妇、多关节炎患者以及临床疑似梅毒患者的血清进行了检测，以查找特异性IgM或IgG抗体。在上述各人群组的血清中，分别发现IgM和/或IgG血清阳性率为30/100（30%）、19/50（7.2%）、10/20（50%）和11/20（55%）。这些结果与挪威卑尔根地区献血者、孕妇以及接受莱姆病血清学检测的患者中Bb血清阳性率分别为4/100（4%）、1/52（2%）和363/5024（7.2%）形成对比，在卑尔根地区莱姆病病例经常被检测到。在坦桑尼亚达累斯萨拉姆，发现了包括游走性红斑、关节炎、心肌炎和中枢神经系统疾病以及蜱叮咬等临床病症，而针对Bb鞭毛抗原的抗体高流行率表明需要进一步开展临床、昆虫学和实验室调查。
