Koziej M, Mańkowski M, Radwan L, Maszczyk Z
Kliniki Chorób Płuc, Warszawie.
Pneumonol Alergol Pol. 1996;64(9-10):687-96.
A 32-year-old, hypertensive, morbidly obese (BMI 49 kg/m2) woman was referred to us suspected of sleep-disordered breathing. Polycythaemia, right heart and respiratory failure, restrictive ventilatory impairment, decreased hypercapnic respiratory drive, high number of very short apneas mostly of central origin (698 vs 530 obstructive), and overnight hypoxaemia were found. The diagnosis of obesity-hypoventilation syndrome was established and the treatment with almitrine, aminophylline and low-calorie diet was started. After 6 months body weight decreased significantly (BMI 38 kg/m2). RBC, spirometry, blood gas analysis, overnight oximetry, hypercapnic respiratory drive and polysomnography showed results within normal limits. Causes, pathophysiology and possible treatment of obesity-hypoventilation syndrome are discussed.
一名32岁、患有高血压、病态肥胖（体重指数49kg/m²）的女性因疑似睡眠呼吸障碍被转诊至我院。检查发现她患有红细胞增多症、右心和呼吸衰竭、限制性通气功能障碍、高碳酸血症呼吸驱动降低、大量主要为中枢性起源的极短呼吸暂停（698次对530次阻塞性呼吸暂停）以及夜间低氧血症。确诊为肥胖低通气综合征后，开始使用烯丙哌三嗪、氨茶碱和低热量饮食进行治疗。6个月后体重显著下降（体重指数38kg/m²）。红细胞计数、肺功能测定、血气分析、夜间血氧饱和度测定、高碳酸血症呼吸驱动和多导睡眠图检查结果均在正常范围内。文中讨论了肥胖低通气综合征的病因、病理生理学及可能的治疗方法。
