Lee Won Y, Mokhlesi Babak
Section of Pulmonary and Critical Care Medicine, The University of Chicago Pritzker School of Medicine, 5841 South Maryland Avenue, Sleep Disorders Center W 4, Chicago, IL 60637, USA.
Crit Care Clin. 2008 Jul;24(3):533-49, vii. doi: 10.1016/j.ccc.2008.02.003.
Obesity hypoventilation syndrome (OHS) is characterized by obesity, daytime hypercapnia, and sleep-disordered breathing in the absence of other known causes of hypercapnia. Because of the global obesity epidemic and the high prevalence of obstructive sleep apnea in the general population, critical care physicians are likely to encounter patients who have acute-on-chronic respiratory failure attributable to OHS in their clinical practice. In this article we define the clinical characteristics of OHS, review its pathophysiology, and discuss the morbidity and mortality associated with OHS. Finally, we offer treatment strategies during ICU management using noninvasive positive pressure ventilation that may guide the physician in the care of these challenging patients.
肥胖低通气综合征（OHS）的特征为肥胖、日间高碳酸血症以及在无其他已知高碳酸血症病因的情况下出现睡眠呼吸紊乱。由于全球肥胖流行以及普通人群中阻塞性睡眠呼吸暂停的高患病率，重症医学医生在临床实践中很可能会遇到因OHS导致急性慢性呼吸衰竭的患者。在本文中，我们定义了OHS的临床特征，回顾了其病理生理学，并讨论了与OHS相关的发病率和死亡率。最后，我们提供了在ICU管理期间使用无创正压通气的治疗策略，这可能会指导医生对这些具有挑战性的患者进行护理。
