Gunasekera S P, Kelly-Borges M, Longley R E
Division of Biomedical Marine Research, Harbor Branch Oceanographic Institution, Inc., Fort Pierce, Florida 34946, USA.
J Nat Prod. 1996 Feb;59(2):161-2. doi: 10.1021/np9600311.
24(R)-Methyl-5 alpha-cholest-7-enyl 3 beta-methoxymethyl ether (1), a new sterol ether, has been isolated from a deep-water marine sponge Scleritoderma sp. cf. paccardi. Compound 1 exhibited in vitro cytotoxicity against the cultured murine P-388 tumor cell line with an IC50 of 2.3 micrograms/mL. The isolation and structure elucidation of 1 by NMR spectroscopy is described.
一种新的甾醇醚，24(R)-甲基-5α-胆甾-7-烯基3β-甲氧基甲基醚(1)，已从一种深水海洋海绵类硬皮海绵属（Scleritoderma sp. cf. paccardi）中分离得到。化合物1对培养的小鼠P-388肿瘤细胞系表现出体外细胞毒性，IC50为2.3微克/毫升。本文描述了通过核磁共振光谱对1进行的分离和结构解析。
