Shen Y C, Tai H R, Chen C Y
Institute of Marine Resources, National Sun Yat-Sen University, Taiwan, Republic of China.
J Nat Prod. 1996 Feb;59(2):173-6. doi: 10.1021/np960046z.
Two new taxoids, taxumairols A (1) and B (2), have been isolated from extracts of the roots of Formosan Taxus mairei (Lemee & Levl.) S. Y. Hu. The structures of 1 and 2 were identified as 5 alpha, 7 beta, 9 alpha, 10 beta, 13 alpha-pentaacetoxy-20-(benzoyloxy)- 2 alpha, 4 alpha-dihydroxytax-11-ene and 2 alpha, 5 alpha, 10 beta,-13 alpha-tetraacetoxy-1 beta, 7 beta, 9 alpha-trihydroxy-4 beta,20-epoxytax-11-ene, primarily on the basis of 1D- and 2D-NMR techniques including DEPT, COSY, and HMBC experiments, as well as chemical correlation with known compounds. Taxumairol A (1) exhibited significant cytotoxicities against murine P-388 and human KB-16, A-549, and HT-29 tumor cell lines.
从台湾红豆杉（Taxus mairei (Lemee & Levl.) S. Y. Hu）根的提取物中分离出两种新的紫杉烷类化合物，即紫杉醇醇A（1）和B（2）。化合物1和2的结构分别鉴定为5α，7β，9α，10β，13α-五乙酰氧基-20-（苯甲酰氧基）-2α，4α-二羟基紫杉-11-烯和2α，5α，10β，-13α-四乙酰氧基-1β，7β，9α-三羟基-4β，20-环氧紫杉-11-烯，主要基于包括DEPT、COSY和HMBC实验在内的一维和二维核磁共振技术，以及与已知化合物的化学关联。紫杉醇醇A（1）对小鼠P-388和人KB-16、A-549及HT-29肿瘤细胞系表现出显著的细胞毒性。
