Liang J, Kingston D G
Department of Chemistry, Virginia Polytechnic Institute and State University, Blacksburg 24061-0212.
J Nat Prod. 1993 Apr;56(4):594-9. doi: 10.1021/np50094a020.
Two new taxane diterpenoids were isolated from the heartwood of Taxus mairei and identified as 5 alpha, 7 beta, 9 alpha, 10 beta, 13 alpha-pentaacetoxy-2 alpha-benzoyloxy-4 alpha, 20-dihydroxytax-11-ene [2] and 7 beta, 9 alpha, 10 beta, 13 alpha, 20-pentaacetoxy-2 alpha-benzoyloxy-4 alpha, 5 alpha-dihydroxytax-11-ene[3]. The structures of 2 and 3 were determined primarily on the basis of analysis of their 1H-nmr, 13C-nmr, 1H-1H 2D COSY, 1H-13C 2D COSY, DEPT, and mass spectra. This is the first report of naturally occurring taxoids lacking a D ring but oxygenated at the 4, 5, and 20 positions.
从南方红豆杉的心材中分离出两种新的紫杉烷二萜类化合物，分别鉴定为5α,7β,9α,10β,13α-五乙酰氧基-2α-苯甲酰氧基-4α,20-二羟基紫杉-11-烯[2]和7β,9α,10β,13α,20-五乙酰氧基-2α-苯甲酰氧基-4α,5α-二羟基紫杉-11-烯[3]。化合物2和3的结构主要通过对其1H-核磁共振、13C-核磁共振、1H-1H二维化学位移相关谱、1H-13C二维化学位移相关谱、无畸变极化转移增强法和质谱分析来确定。这是首次报道天然存在的缺乏D环但在4、5和20位被氧化的紫杉烷类化合物。
