Cedoz J P, Wendling D, Viel J F
Rheumatology Service, Centre Hospitalier Universitaire de Besançon, France.
J Rheumatol. 1995 Oct;22(10):1884-90.
To study the association between the B7 cross reactive group (B7, B40) and spondyloarthropathy (SpA), taking into account patients with atypical features.
We studied the main clinical and paraclinical features of 51 patients with rheumatoid arthritis, 55 with SpA, 120 with mechanical diseases, and 160 with inflammatory rheumatism not fulfilling the diagnostic criteria currently used. This descriptive analysis was performed using multiple correspondence factorial analysis to identify subgroups among unclassified patients and select SpA variants. We compared HLA frequencies among these groups versus a control group.
We identified a subgroup close to the axial SpA and related to B7 (OR:5.91, p = 0.0008), whereas B40 is related to patients close to the peripheral SpA.
B7 is related to axial SpA variants manifested by inflammatory low back pain according to Calin's criteria, with either extraarticular signs or sacroiliitis. Followup of such patients is required to determine whether their disease is a new entity or can be considered SpA.
研究B7交叉反应组（B7、B40）与脊柱关节病（SpA）之间的关联，同时考虑具有非典型特征的患者。
我们研究了51例类风湿关节炎患者、55例SpA患者、120例机械性疾病患者以及160例不符合目前所用诊断标准的炎性风湿病患者的主要临床和辅助临床特征。使用多重对应因子分析进行描述性分析，以识别未分类患者中的亚组并选择SpA变体。我们比较了这些组与对照组之间的HLA频率。
我们识别出一个接近轴向SpA且与B7相关的亚组（比值比：5.91，p = 0.0008），而B40与接近外周SpA的患者相关。
根据卡林标准，B7与以炎性腰背痛为表现、伴有关节外体征或骶髂关节炎的轴向SpA变体相关。需要对这些患者进行随访，以确定他们的疾病是一种新的疾病实体还是可被视为SpA。
