Arend O, Remky A, Solbach U, Harris A, Wolf S, Reim M
Augenklinik, Med. Fak. der RWTH Aachen.
Klin Monbl Augenheilkd. 1996 Aug-Sep;209(2-3):163-70. doi: 10.1055/s-2008-1035298.
Fluorescein angiography with a scanning laser ophthalmoscope allows the quantification of morphologic and dynamic changes in the retina. In two patients with central retinal vein occlusion we monitored the progression of the cystoid macular edema (CME) and changes of microcirculation with a follow up of 4 to 6 months.
Two patients with central retinal vein occlusion and CME were examined by means of digital fluorescein angiography. Arteriovenous passage times and macular capillary blood velocities in combination with quantifications of the macular angioarchitecture and the extent of the CME were evaluated.
Hemodilution therapy improved retinal circulation, whereas macular circulation and the severity of the CME remained unchanged. With persisting CME oral acetazolamid therapy was initiated. Oral Acetazolamide led to resorption of the cystoid edema in tandem with improved macular circulation. The capillary density was altered but remained unchanged over time.
By means of digital analysis of fluorescein angiograms a detailed monitoring and retinal and macular dynamics, macular morphology is possible. In these two cases CME improved after Acetazolamide and moreover retinal circulation returned to normal conditions.
使用扫描激光检眼镜进行荧光素血管造影可对视网膜的形态和动态变化进行量化。我们对两名视网膜中央静脉阻塞患者的黄斑囊样水肿（CME）进展和微循环变化进行了4至6个月的随访监测。
对两名患有视网膜中央静脉阻塞和CME的患者进行了数字荧光素血管造影检查。评估了动静脉通过时间和黄斑区毛细血管血流速度，并结合黄斑血管结构量化和CME范围进行分析。
血液稀释疗法改善了视网膜循环，而黄斑循环和CME的严重程度保持不变。由于CME持续存在，开始采用口服乙酰唑胺治疗。口服乙酰唑胺使囊样水肿消退，同时黄斑循环得到改善。毛细血管密度发生了改变，但随时间保持不变。
通过对荧光素血管造影片进行数字分析，可以对视网膜和黄斑动态、黄斑形态进行详细监测。在这两个病例中，乙酰唑胺治疗后CME得到改善，而且视网膜循环恢复到正常状态。
