Otto N, Thieler H, Schmidt U
Z Urol Nephrol. 1977 May;70(5):323-9.
18 dialysators C-DAK 5 and 4 each were again used in the same patients with chronic dialysis under the same conditions of dialysis and regeneration (short-acting dialyses of more than 3.5 h with 1 C-DAK 5 or 2 parallel acting C-DAK 4, respectively). A volume of the blood compartment of more than 70% of the initial value was regarded as criterion for the further usability. Thus, model 5 could be used on an average 3.7 times, model 4, however, 6.3 times (p less than 0.0001). Already at the end of the 3rd use in model 5 the capillary volume decreased below 63%, in model 4 only below 88%. The volumetrically determined ultrafiltration showed a decrease parallel to the volume of the blood compartment -- with the same differences between the two models of the C-DAK. In model 15 the effectiveness concerning the elimination of creatinine and urea clearly decreased after the 2nd use, whereas it did not reveal a change also in an application four times repeated. The larger coagulation processes in a more than once repeated use of the C-DAK 5 -- with adequate losses of blood -- are explained with the large length of the capillary and the other distribution of blood with regard to the cross section of the capillary. Summarizing we can say that in chronic routine dialyses -- without testing the individual exemplars -- model 5 of the C-DAK can be used twice, model 4, however, four times.
18个C - DAK 5型透析器和4个C - DAK 4型透析器再次用于同一组慢性透析患者,透析和再生条件相同(分别使用1个C - DAK 5进行超过3.5小时的短效透析,或2个并行的C - DAK 4)。血液腔室体积超过初始值的70%被视为进一步可用的标准。因此,5型模型平均可使用3.7次,而4型模型平均可使用6.3次(p小于0.0001)。在5型模型第3次使用结束时,毛细血管体积已降至63%以下,而4型模型仅降至88%以下。通过体积测定的超滤量与血液腔室体积平行下降——C - DAK两种模型之间存在相同差异。在15型模型中,第2次使用后肌酐和尿素清除效率明显下降,而在重复使用4次的情况下也未显示出变化。C - DAK 5多次重复使用时较大的凝血过程——伴有相当量的血液损失——可通过毛细血管较长以及血液在毛细血管横截面上的其他分布情况来解释。综上所述,我们可以说,在慢性常规透析中——不检测单个样本——C - DAK 5型模型可使用两次,而4型模型可使用四次。