过氧化物酶体脂肪酰辅酶A氧化酶基因的靶向破坏：假性新生儿肾上腺脑白质营养不良小鼠模型的建立 - Suppr

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超能文献

Targeted disruption of the peroxisomal fatty acyl-CoA oxidase gene: generation of a mouse model of pseudoneonatal adrenoleukodystrophy.

作者信息

Fan C Y, Pan J, Chu R, Lee D, Kluckman K D, Usuda N, Singh I, Yeldandi A V, Rao M S, Maeda N, Reddy J K

机构信息

Department of Pathology, Northwestern University Medical School Chicago, Illinois 60611, USA.

出版信息

Ann N Y Acad Sci. 1996 Dec 27;804:530-41. doi: 10.1111/j.1749-6632.1996.tb18643.x.

DOI:10.1111/j.1749-6632.1996.tb18643.x

PMID:8993571

Abstract

摘要

相似文献

Targeted disruption of the peroxisomal fatty acyl-CoA oxidase gene: generation of a mouse model of pseudoneonatal adrenoleukodystrophy.过氧化物酶体脂肪酰辅酶A氧化酶基因的靶向破坏：假性新生儿肾上腺脑白质营养不良小鼠模型的建立

Ann N Y Acad Sci. 1996 Dec 27;804:530-41. doi: 10.1111/j.1749-6632.1996.tb18643.x.

Large deletion of the peroxisomal acyl-CoA oxidase gene in pseudoneonatal adrenoleukodystrophy.假性新生儿肾上腺脑白质营养不良中过氧化物酶体酰基辅酶A氧化酶基因的大片段缺失。

J Clin Invest. 1994 Aug;94(2):526-31. doi: 10.1172/JCI117365.

Peroxisomal and mitochondrial fatty acid beta-oxidation in mice nullizygous for both peroxisome proliferator-activated receptor alpha and peroxisomal fatty acyl-CoA oxidase. Genotype correlation with fatty liver phenotype.过氧化物酶体增殖物激活受体α和过氧化物酶体脂肪酰辅酶A氧化酶双基因敲除小鼠的过氧化物酶体和线粒体脂肪酸β氧化。基因型与脂肪肝表型的相关性。

J Biol Chem. 1999 Jul 2;274(27):19228-36. doi: 10.1074/jbc.274.27.19228.

Steatohepatitis, spontaneous peroxisome proliferation and liver tumors in mice lacking peroxisomal fatty acyl-CoA oxidase. Implications for peroxisome proliferator-activated receptor alpha natural ligand metabolism.缺乏过氧化物酶体脂肪酰辅酶A氧化酶的小鼠中的脂肪性肝炎、自发性过氧化物酶体增殖和肝肿瘤。对过氧化物酶体增殖物激活受体α天然配体代谢的影响。

J Biol Chem. 1998 Jun 19;273(25):15639-45. doi: 10.1074/jbc.273.25.15639.

A new peroxisomal disorder with enlarged peroxisomes and a specific deficiency of acyl-CoA oxidase (pseudo-neonatal adrenoleukodystrophy).一种新的过氧化物酶体疾病，伴有过氧化物酶体增大及酰基辅酶A氧化酶特异性缺乏（假性新生儿肾上腺脑白质营养不良）。

Am J Hum Genet. 1988 Mar;42(3):422-34.

Three for the price of one knockout--a mouse model of a congenital peroxisomal disorder, steatohepatitis, and hepatocarcinogenesis.一价三得——一种先天性过氧化物酶体疾病、脂肪性肝炎和肝癌发生的小鼠模型。

Hepatology. 1999 Feb;29(2):606-8. doi: 10.1002/hep.510290247.

Pristanic acid does not accumulate in peroxisomal acyl-CoA oxidase deficiency: evidence for a distinct peroxisomal pristanyl-CoA oxidase.

J Inherit Metab Dis. 1991;14(5):681-4. doi: 10.1007/BF01799934.

Peroxisome proliferator-activated receptor alpha-responsive genes induced in the newborn but not prenatal liver of peroxisomal fatty acyl-CoA oxidase null mice.过氧化物酶体脂肪酸酰基辅酶A氧化酶缺失小鼠新生肝脏而非产前肝脏中诱导产生的过氧化物酶体增殖物激活受体α反应性基因。

Exp Cell Res. 2001 Aug 1;268(1):70-6. doi: 10.1006/excr.2001.5266.

Straight-chain acyl-CoA oxidase knockout mouse accumulates extremely long chain fatty acids from alpha-linolenic acid: evidence for runaway carousel-type enzyme kinetics in peroxisomal beta-oxidation diseases.直链酰基辅酶A氧化酶基因敲除小鼠从α-亚麻酸积累超长链脂肪酸：过氧化物酶体β-氧化疾病中失控的循环式酶动力学证据。

Mol Genet Metab. 2002 Feb;75(2):108-19. doi: 10.1006/mgme.2001.3279.

First prenatal diagnosis of acyl-CoA oxidase deficiency.

J Inherit Metab Dis. 1990;13(3):371-4. doi: 10.1007/BF01799398.

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