Ikeda U, Yamamoto K, Shimada K
Department of Cardiology, Jichi Medical School, Tochigi, Japan.
Clin Cardiol. 1997 Jan;20(1):7-10. doi: 10.1002/clc.4960200104.
Advances in the understanding of the biochemistry of the mechanism of hemostasis have led to the development of sensitive methods for determining levels of markers which reflect thrombin activity (thrombin-antithrombin III complex, fibrinopeptide A, F1 + 2 fragment), active fibrinolysis (D-dimer, plasmin-alpha 2-plasmin inhibitor complex), and platelet activity (platelet factor 4, beta-thromboglobulin) in vivo. Measurement of these markers may be useful in identifying patients with various cardiovascular disorders at high risk of thromboembolism.
对止血机制生物化学认识的进展，已促成了一些灵敏方法的开发，这些方法可用于测定反映体内凝血酶活性（凝血酶 - 抗凝血酶III复合物、纤维蛋白肽A、F1 + 2片段）、纤维蛋白溶解活性（D - 二聚体、纤溶酶 - α2 - 纤溶酶抑制剂复合物）以及血小板活性（血小板因子4、β - 血小板球蛋白）的标志物水平。测定这些标志物可能有助于识别有血栓栓塞高风险的各种心血管疾病患者。
