防止尿嘧啶进入DNA。

Precluding uracil from DNA.

作者信息

Vassylyev D G, Morikawa K

机构信息

International Institute for Advanced Research, Central Research Laboratories, Matsushita Electric Industrial Company Limited, Kyoto, Japan.

出版信息

Structure. 1996 Dec 15;4(12):1381-5. doi: 10.1016/s0969-2126(96)00145-1.

DOI:10.1016/s0969-2126(96)00145-1

PMID:8994964

Abstract

Two enzymes, dUTP pyrophosphatase and uracil-DNA glycosylase, prevent the misincorporation of uracil into the genome in distinct manners. The atomic structures of these proteins complexed with substrate analogs reveal the structural basis for uracil recognition and suggest a novel mechanism of DNA repair.

摘要

两种酶，即dUTP焦磷酸酶和尿嘧啶-DNA糖基化酶，以不同方式防止尿嘧啶错误掺入基因组。这些与底物类似物复合的蛋白质的原子结构揭示了尿嘧啶识别的结构基础，并提出了一种新的DNA修复机制。