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新生期用雌激素处理的小鼠子宫上皮的超微结构

Ultrastructure of the uterine epithelium of mice treated neonatally with estrogen.

作者信息

Mori T

出版信息

Acta Anat (Basel). 1977;99(4):462-8. doi: 10.1159/000144871.

DOI:10.1159/000144871
PMID:899711
Abstract

In neonatally estrogenized mice, uterine epithelial cells possessed a few microvilli on the fuzzy-appearing apical surface, regardless of the presence or the absence of estrogen. The cells showed well-developed rough endoplasmic reticulum and a large number of mitochondria, suggesting that the cells were actively functioning. At 13 months of age, the uterine epithelium of neonatally estrogenized mice was sometimes stratified and squamous. Spherical basal cells like those appearing in cancerous vagina in estrogen-treated mice made their appearance. These cells may have the capacity of autonomous proliferation.

摘要

在新生期经雌激素处理的小鼠中,无论有无雌激素,子宫上皮细胞在模糊不清的顶端表面都有一些微绒毛。细胞显示出发育良好的粗面内质网和大量线粒体,表明这些细胞在活跃地发挥功能。在13个月大时,新生期经雌激素处理的小鼠的子宫上皮有时会分层且呈鳞状。出现了类似于雌激素处理的小鼠癌性阴道中出现的球形基底细胞。这些细胞可能具有自主增殖的能力。

相似文献

1
Ultrastructure of the uterine epithelium of mice treated neonatally with estrogen.新生期用雌激素处理的小鼠子宫上皮的超微结构
Acta Anat (Basel). 1977;99(4):462-8. doi: 10.1159/000144871.
2
Effects of progesterone plus estradiol on vaginal epithelium showing estrogen-independent proliferation and cornification in neonatally estrogenized and androgenized mice.孕酮加雌二醇对新生期经雌激素化和雄激素化小鼠阴道上皮的影响,该阴道上皮表现出非雌激素依赖性增殖和角化。
Proc Jpn Acad. 1976 Dec;52(10):583-6.
3
Occurrence of permanent changes in vaginal and uterine epithelia in mice treated neonatally with progestin, estrogen and aromatizable or non-aromatizable androgens.新生期用孕激素、雌激素以及可芳香化或不可芳香化雄激素处理的小鼠阴道和子宫上皮出现永久性变化。
Endocrinol Jpn. 1976 Aug;23(4):327-32. doi: 10.1507/endocrj1954.23.327.
4
Occurrence of permanent changes in vaginal and uterine epithelia in mice treated neonatally with progestin, estrogen and aromatizable or non-aromatizable androgens.
Endocrinol Jpn. 1977 Aug;23(4):328-32.
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Ultrastructural characteristics of the vaginal epithelium of neonatally estrogenized mice in response to subsequent estrogen treatment.
Endocrinol Jpn. 1976 Aug;23(4):341-5.
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Additional effects of postpuberal estrogen injections on the vaginal epithelium in neonatally estrogenized mice.青春期后注射雌激素对新生期经雌激素处理小鼠阴道上皮的额外影响。
Acta Anat (Basel). 1978;100(4):369-74. doi: 10.1159/000144919.
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Effect of later treatment with estrogen on reproductive tract lesions in neonatally estrogenized female mice.雌激素后期治疗对新生期雌激素化雌性小鼠生殖道病变的影响。
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Effects of postpubertal oestrogen injections on mitotic activity of vaginal and uterine epithelial cells in mice treated neonatally with oestrogen.青春期后注射雌激素对新生期经雌激素处理的小鼠阴道和子宫上皮细胞有丝分裂活性的影响。
J Endocrinol. 1975 Jan;64(1):133-40. doi: 10.1677/joe.0.0640133.
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引用本文的文献

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Blockade by vitamin A of the occurrence of permanent vaginal changes in mice treated neonatally with 5alpha-dihydrotestosterone.维生素A对新生期用5α-二氢睾酮处理的小鼠永久性阴道变化发生的阻断作用。
Anat Embryol (Berl). 1979 Jan 30;155(2):127-34. doi: 10.1007/BF00305746.