Skaare A, Eide G, Herlofson B, Barkvoll P
Department of Oral Surgery and Oral Medicine, Faculty of Dentistry, University of Oslo, Norway.
J Clin Periodontol. 1996 Dec;23(12):1100-3. doi: 10.1111/j.1600-051x.1996.tb01810.x.
SLS-containing toothpaste has previously been shown to cause oral mucosal desquamations when used in an experimental cap splint model. The aim of the present study was to examine the effect of toothpastes containing SLS in combination with triclosan on oral mucosal desquamation in a similar cap splint model system. It has previously been shown that the antibacterial agent triclosan also may have anti-inflammatory properties. The concentration of triclosan in the experimental toothpastes was 0.3%, while SLS varied from 1.5% to 3%. No oral mucosal desquamations were observed after use of a 1.5% SLS 0.3% triclosan containing toothpaste, contrary to the positive control toothpaste that contained 1.5% SLS without triclosan. Furthermore, a statistically significant reduction in severe desquamations was observed after use of a toothpaste containing 3% SLS-0.3% triclosan compared with the positive control. It may thus be suggested that triclosan exerts a moderating effect on desquamative reactions caused by SLS and that the effect is dependent on the relative amount of triclosan and SLS in the toothpastes.
先前的研究表明，在实验性帽式夹板模型中使用含月桂醇硫酸酯钠（SLS）的牙膏会导致口腔黏膜剥脱。本研究的目的是在类似的帽式夹板模型系统中，研究含SLS与三氯生组合的牙膏对口腔黏膜剥脱的影响。先前的研究表明，抗菌剂三氯生也可能具有抗炎特性。实验牙膏中三氯生的浓度为0.3%，而SLS的浓度在1.5%至3%之间变化。使用含1.5% SLS和0.3%三氯生的牙膏后，未观察到口腔黏膜剥脱，这与含1.5% SLS但不含三氯生的阳性对照牙膏相反。此外，与阳性对照相比，使用含3% SLS - 0.3%三氯生的牙膏后，严重剥脱的情况在统计学上有显著减少。因此，可以认为三氯生对SLS引起的剥脱反应有调节作用，且这种作用取决于牙膏中三氯生和SLS的相对含量。
